Mast cell activation (MCA) accompanies diverse physiologic and pathologic processes and
is one of the more frequently encountered conditions in medicine. MCA-related symptoms …

Mastocytosis is a myeloid neoplasm defined by expansion and focal accumulation of clonal
mast cells (MCs) in one or more organs. The disease exhibits a complex pathology and may …

Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

This practice parameter update focuses on 7 areas in which there are new evidence and
new recommendations. Diagnostic criteria for anaphylaxis have been revised, and patterns …

Drug hypersensitivity reactions (DHRs) to intravenous drugs can be severe and might leave
patients and doctors in a difficult position where an essential treatment or intervention has to …

Our current recommendations for diagnosing and treating primary mast cell (MC) activation
syndrome make use of the latest studies and consensus guidelines for clinically recognizing …

Mastocytosis is an emerging differential diagnosis in patients with more or less specific
mediator‐related symptoms. In some of these patients, typical skin lesions are found and the …

Hymenoptera venom allergy is an epidemiologically underestimated condition representing
an important cause of morbidity worldwide. Preventing future allergic reactions in patients …

The most abundant prestored enzyme of human mast cell secretory granules is the serine-
protease tryptase. In humans, there are four tryptase isoforms, but only two of them, namely …

Pediatric mastocytosis is a heterogeneous disease characterized by accumulation of mast
cells in the skin and less frequently in other organs. Somatic or germline mutations in the KIT …