Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor
microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each …

Transgenic approaches are instrumental for labeling and manipulating cells and cellular
machineries in vivo. Transgenes have traditionally been static entities that remained …

The CRISPR/Cas9 system provides a powerful tool for genome editing in various model
organisms, including zebrafish. The establishment of targeted gene-disrupted zebrafish …

The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …

As an animal's surface area expands during development, skin cell populations must quickly
respond to maintain sufficient epithelial coverage. Despite much progress in understanding …

Bile salt synthesis, secretion into the intestinal lumen, and resorption in the ileum occur in all
vertebrate classes. In mammals, bile salt composition is determined by host and microbial …

Attaining proper organ size during development and regeneration hinges on the activity of
mitogenic factors. Here, we performed a large-scale chemical screen in embryonic zebrafish …

Re-epithelialization of cutaneous wounds in adult mammals takes days to complete and
relies on numerous signalling cues and multiple overlapping cellular processes that take …

Abstract Leukotriene B4 (LTB4) is a potent lipid chemoattractant driving inflammatory
responses during host defense, allergy, autoimmune and metabolic diseases. Gradients of …

SWI/SNF-related intellectual disability disorders (SSRIDDs) are rare neurodevelopmental
disorders characterized by developmental disability, coarse facial features, and fifth digit/nail …