Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The mammalian target of rapamycin, mTOR is the master regulator of a cell's growth and
metabolic state in response to nutrients, growth factors and many extracellular cues. Its …

Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Outer radial glial (oRG) cells are a population of neural stem cells prevalent in the
developing human cortex that contribute to its cellular diversity and evolutionary expansion …

The mechanistic target of rapamycin (mTOR) signaling pathway is an essential regulator of
numerous cellular activities such as metabolism, growth, proliferation, and survival. The …

Essential to development, primary cilia are microtubule-based cellular organelles that
protrude from the surface of cells. Acting as cellular antenna, primary cilia play central roles …

Tuberous sclerosis complex (TSC) and focal cortical dysplasia (FCD) are focal
malformations of cortical development (FMCDs) that are highly associated with intractable …

Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to
mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a …

During the past decade, there have been considerable advances in understanding of the
genetic and morphogenic processes underlying cortical malformations and developmental …

The primary cilium, a microtubule based organelle protruding from the cell surface and
acting as an antenna in multiple signaling pathways, takes center stage in the formation of …