An improved MS2 system for accurate reporting of the mRNA life cycle
The MS2–MCP system enables researchers to image multiple steps of the mRNA life cycle
with high temporal and spatial resolution. However, for short-lived mRNAs, the tight binding …
with high temporal and spatial resolution. However, for short-lived mRNAs, the tight binding …
Cytoplasmic RNA-protein particles exhibit non-Gaussian subdiffusive behavior
The cellular cytoplasm is a complex, heterogeneous environment (both spatially and
temporally) that exhibits viscoelastic behavior. To further develop our quantitative insight into …
temporally) that exhibits viscoelastic behavior. To further develop our quantitative insight into …
Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast
BM Zid, EK O'Shea - Nature, 2014 - nature.com
A universal feature of the response to stress and nutrient limitation is transcriptional
upregulation of genes that encode proteins important for survival. Under many such …
upregulation of genes that encode proteins important for survival. Under many such …
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease primarily
affecting motor neurons. Mutations in the gene encoding TDP-43 cause some forms of the …
affecting motor neurons. Mutations in the gene encoding TDP-43 cause some forms of the …
Designer protein assemblies with tunable phase diagrams in living cells
M Heidenreich, JM Georgeson, E Locatelli… - Nature Chemical …, 2020 - nature.com
Protein self-organization is a hallmark of biological systems. Although the physicochemical
principles governing protein–protein interactions have long been known, the principles by …
principles governing protein–protein interactions have long been known, the principles by …
Transmitting the message: intracellular mRNA localization
The intracellular localization of mRNA is an important mechanism for targeting proteins to
their sites of function. Localized transcripts play key roles ranging from body axis …
their sites of function. Localized transcripts play key roles ranging from body axis …
Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae
Targeted mRNA localization is a likely determinant of localized protein synthesis. To
investigate whether mRNAs encoding mitochondrial proteins (mMPs) localize to …
investigate whether mRNAs encoding mitochondrial proteins (mMPs) localize to …
Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis
Mitochondria are dynamic organelles that must precisely control their protein composition
according to cellular energy demand. Although nuclear-encoded mRNAs can be localized to …
according to cellular energy demand. Although nuclear-encoded mRNAs can be localized to …
GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function
AS Burguete, S Almeida, FB Gao, R Kalb, MR Akins… - Elife, 2015 - elifesciences.org
Microsatellite expansions are the leading cause of numerous neurodegenerative disorders.
Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with …
Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with …
Mitochondrial protein heterogeneity stems from the stochastic nature of co-translational protein targeting in cell senescence
A decline in mitochondrial function is a hallmark of aging and neurodegenerative diseases.
It has been proposed that changes in mitochondrial morphology, including fragmentation of …
It has been proposed that changes in mitochondrial morphology, including fragmentation of …