Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules.
The shape-forming feature of single-stranded oligonucleotides provides high affinity and …

Aggregation of alpha-synuclein (α-Syn) drives Parkinson's disease (PD), although the initial
stages of self-assembly and structural conversion have not been directly observed inside …

Amyloid β-peptide oligomer (AβO) is widely acknowledged as the promising biomarker for
the diagnosis of Alzheimer's disease (AD). In this work, we designed a three-dimensional …

Extracellular deposition of β-amyloid (Aβ) peptide aggregates is a major characteristic of
Alzheimer's disease (AD) brain. Because Aβ peptide aggregates aggravate neuropathy and …

Amyloid-β oligomer (AβO) is widely regarded as a reliable biomarker for the early diagnosis
of Alzheimer's disease (AD). In this study, a signal on–off ratiometric electrochemical …

As a tumor biomarker, the accumulation of amyloid β oligomers (Aβo) in the brain has been
suggested as a key feature in the pathogenesis and progression of Alzheimer's disease …

Aptamers are single stranded oligonucleotides with specific recognition and binding ability
to target molecules, which can be obtained by Systematic Evolution of Ligands by …

A high-efficiency sensing system for α-synuclein (α-Syn) oligomers was designed based on
a novel one dimensional (1D)/2D structural nanohybrid (denoted as CoMnZIF@ CNF) of …

TDP-43 accumulates in nerve cells of nearly all cases of amyotrophic lateral sclerosis (ALS;
the commonest form of motor neuron disease) and in the majority of Tau-negative …