The exposome concept refers to the totality of exposures from a variety of external and
internal sources including chemical agents, biological agents, or radiation, from conception …

The concept of the exposome was introduced over 15 years ago to reflect the important role
that the environment exerts on health and disease. While originally viewed as a call-to-arms …

Derived from the term exposure, the exposome is an omic-scale characterization of the
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …

Human serum albumins (HSAs) are synthesized in the liver and are the most abundant
proteins in plasma of healthy human. They play an important role in the pathophysiological …

The reaction products of electrophiles in vivo can be measured as adducts to the abundant
proteins, hemoglobin (Hb), and human serum albumin (HSA), in human blood samples …

The proportion of total deaths attributable to environmental factors is estimated to be 23% of
global deaths and 22% of global disability-adjusted life years (DALYs) according to one …

Chronic inflammation is an established risk factor for colorectal cancer. To study reactive
products of gut inflammation and redox signaling on colorectal cancer development, we …

Metabolism of chemicals from the diet, exposures to xenobiotics, the microbiome, and
lifestyle factors (eg, smoking, alcohol intake) produce electrophiles that react with …

Background: Increasing evidence suggests that exposure to air pollution during pregnancy
is associated with adverse pregnancy outcomes. However, biomarkers associated with air …

The presence of a dynamic and balanced equilibrium between the production of reactive
oxygen (ROS) and nitrogen (RNS) species and the in‐house antioxidant defense …