Importance of microbial natural products and the need to revitalize their discovery

AL Demain - Journal of industrial microbiology and …, 2014 - academic.oup.com
Microbes are the leading producers of useful natural products. Natural products from
microbes and plants make excellent drugs. Significant portions of the microbial genomes are …

Glycopeptide antibiotics: back to the future

MS Butler, KA Hansford, MAT Blaskovich… - The Journal of …, 2014 - nature.com
Glycopeptide antibiotics have been a key weapon in the fight against bacterial infections for
over half a century, with the progenitors, vancomycin (1) and teicoplanin (2), still used …

Antibiotic discovery in the twenty-first century: current trends and future perspectives

S Donadio, S Maffioli, P Monciardini, M Sosio… - The Journal of …, 2010 - nature.com
New antibiotics are necessary to treat microbial pathogens that are becoming increasingly
resistant to available treatment. Despite the medical need, the number of newly approved …

Emerging roles of glycopeptide antibiotics: Moving beyond gram-positive bacteria

Y Acharya, S Bhattacharyya, G Dhanda… - ACS Infectious …, 2021 - ACS Publications
Glycopeptides, a class of cell wall biosynthesis inhibitors, have been the antibiotics of choice
against drug-resistant Gram-positive bacterial infections. Their unique mechanism of action …

Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage

B Zhang, W Phetsang, MRL Stone, S Kc… - Communications …, 2023 - nature.com
Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are
desperately needed, as are research tools to aid in their discovery and development …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010

DJ Harvey - Mass spectrometry reviews, 2015 - Wiley Online Library
This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review

D Stojković, J Petrović, T Carević, M Soković, K Liaras - Antibiotics, 2023 - mdpi.com
This narrative review paper provides an up-to-date overview of the potential of novel
synthetic and semisynthetic compounds as antibacterials that target virulence traits in …

Naturally Occurring Organohalogen Compounds—A Comprehensive Review

GW Gribble - Naturally Occurring Organohalogen Compounds, 2023 - Springer
The present volume is the third in a trilogy that documents naturally occurring
organohalogen compounds, bringing the total number—from fewer than 25 in 1968—to …

Chemical tailoring of teicoplanin with site-selective reactions

TP Pathak, SJ Miller - Journal of the American Chemical Society, 2013 - ACS Publications
Semisynthesis of natural product derivatives combines the power of fermentation with
orthogonal chemical reactions. Yet, chemical modification of complex structures represents …

Semisynthetic teicoplanin derivatives with dual antimicrobial activity against SARS-CoV-2 and multiresistant bacteria

I Bereczki, V Vimberg, E Lőrincz, H Papp, L Nagy… - Scientific reports, 2022 - nature.com
Patients infected with SARS-CoV-2 risk co-infection with Gram-positive bacteria, which
severely affects their prognosis. Antimicrobial drugs with dual antiviral and antibacterial …