Thyroid hormone system disrupting compounds are considered potential threats for human
and environmental health. Multiple adverse outcome pathways (AOPs) for thyroid hormone …

Despite advances in toxicity testing and the development of new approach methodologies
(NAMs) for hazard assessment, the ecological risk assessment (ERA) framework for …

Thyroid hormones (THs) are involved in the regulation of many important physiological and
developmental processes, including vertebrate eye development. Thyroid hormone system …

Both amphibian metamorphosis assay (AMA) and larval amphibian growth and
development assay (LAGDA) can detect thyroid-mediated modality and adversity on the …

Iodine is essential for the production of thyroid hormones. Perchlorate is an environmental
contaminant that interferes with iodine uptake into the thyroid gland to reduce thyroid …

The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied
molecular mechanism through which environmental chemicals can potentially cause thyroid …

Abstract According to the World Health Organisation and European Commission definitions,
substances shall be considered as having endocrine disrupting properties if they show …

The amphibian metamorphosis assay (AMA; US Environmental Protection Agency [USEPA]
test guideline 890.1100 and Organisation for Economic Co‐Operation and Development test …

Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid
hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger …

An adverse outcome pathway (AOP) framework maps the sequence of events leading to
adverse outcomes from chemical exposures, providing a mechanistic understanding often …