Frailty in aging marks a state of decreased reserves resulting in increased vulnerability to
adverse outcomes when exposed to stressors. This Perspective synthesizes the evidence …

Depression is currently among the top five leading causes of the global burden of disease.
Chronic unpredictable mild stress (CUMS) is currently the most commonly used, reliable …

Adult neurogenesis in the dentate gyrus of the hippocampus is regulated by specific
microglia groups and functionally implicated in behavioral responses to stress. However, the …

Studies suggest that heightened peripheral inflammation contributes to the pathogenesis of
major depressive disorder. We investigated the effect of chronic social defeat stress, a …

Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

Susceptibility and resilience to stress depend on 1) the timing of the exposure with respect to
development, 2) the time across the life span at which effects are measured, and 3) the …

Sleep problems are widely prevalent and associated with various comorbidities including
anxiety. Valerian (Valeriana officinalis L.) is a popular herbal medicine used as a sleep aid …

Contemplative practices, such as meditation and yoga, are increasingly popular among the
general public and as topics of research. Beneficial effects associated with these practices …

Preclinical and clinical studies suggest that inflammation and vascular dysfunction
contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress …

Resilience is the process that allows individuals to adapt to adverse conditions and recover
from them. This process is favored by individual qualities that have been amply studied in …