The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Introduction to traditional medicine and their role in prevention and treatment of emerging and re-emerging diseases

SAA Rizvi, GP Einstein, OL Tulp, F Sainvil, R Branly - Biomolecules, 2022 - mdpi.com
Infectious diseases have been a threat to human health globally. The relentless efforts and
research have enabled us to overcome most of the diseases through the use of antiviral and …

Advances in the regulation of macrophage polarization by mesenchymal stem cells and implications for ALI/ARDS treatment

C Liu, K Xiao, L Xie - Frontiers in Immunology, 2022 - frontiersin.org
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common condition
with high mortality. ALI/ARDS is caused by multiple etiologies, and the main clinical …

A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome

A Taher, M Lashgari, L Sedighi, F Rahimi-Bashar… - Pharmacological …, 2021 - Springer
Background We designed this single-centre clinical trial to assess the potential benefits of N-
Acetylcysteine (NAC) in patients with COVID19-associated acute respiratory distress …

Preliminary findings on the association of the lipid peroxidation product 4-hydroxynonenal with the lethal outcome of aggressive COVID-19

N Žarković, B Orehovec, L Milković, B Baršić, F Tatzber… - Antioxidants, 2021 - mdpi.com
Major findings of the pilot study involving 21 critically ill patients during the week after
admission to the critical care unit specialized for COVID-19 are presented. Fourteen patients …

N‐Acetylcysteine and Other Sulfur‐Donors as a Preventative and Adjunct Therapy for COVID‐19

HN du Preez, C Aldous, HG Kruger… - Advances in …, 2022 - Wiley Online Library
The airway epithelial glycocalyx plays an important role in preventing severe acute
respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial …

Nutritional deficiencies that may predispose to long COVID

JV Schloss - Inflammopharmacology, 2023 - Springer
Multiple nutritional deficiencies (MND) confound studies designed to assess the role of a
single nutrient in contributing to the initiation and progression of disease states. Despite the …

N-Acetylcysteine and its immunomodulatory properties in humans and domesticated animals

S Tieu, A Charchoglyan, L Paulsen… - Antioxidants, 2023 - mdpi.com
N-acetylcysteine (NAC), an acetylated derivative of the amino acid L-cysteine, has been
widely used as a mucolytic agent and antidote for acetaminophen overdose since the 1960s …

Use of thiols in the treatment of COVID-19: current evidence

M Cazzola, P Rogliani, SS Salvi, J Ora, MG Matera - Lung, 2021 - Springer
There is a possible role for oxidative stress, a state characterized by an altered balance
between the production of free radicals or reactive oxygen species (ROS) and antioxidant …

Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19

L Kundura, S Gimenez, R Cezar, S André… - Journal of Allergy and …, 2022 - Elsevier
Background Lymphopenia is predictive of survival in patients with coronavirus disease 2019
(COVID-19). Objective The aim of this study was to understand the cause of the lymphocyte …