Background Chemotherapy-associated liver injury is a major cause for concern when
treating patients with colorectal liver metastases. The aim of this review was to determine the …

Drug-induced liver injury (DILI) has a very variable clinical and biochemical phenotype and
differs widely in severity, from mild injury to life-threatening liver failure. Chronic injury has …

Many chemotherapeutics used for cancer treatments encounter issues during delivery to
tumors in vivo and may have high levels of systemic toxicity due to their nonspecific …

Background The optimal duration, safety, and benefit of preoperative chemotherapy in
patients with colorectal liver metastases (CLM) are unclear. We evaluated the association …

Purpose Oxaliplatin-based chemotherapy can cause hepatic sinusoidal injury, with resultant
sinusoidal damage and portal hypertension. We sought to explore the relationship between …

Background Chemotherapy-induced liver injury is a considerable problem in patients
undergoing surgery for colorectal liver metastases, since an increase in postoperative …

The liver is the largest parenchymatous organ of the body and central for intermediate
metabolism. Its close contact to the portal blood streaming back from the gut and the …

Introduction: All anticancer drugs can cause idiosyncratic liver injury. Therefore,
hepatoprotective agents assume particular importance to preserve liver function. Hepatic …

Introduction Liver failure after hepatectomy remains the most feared postoperative
complication. Many risk factors are already known, related to patient's comorbidities …

Background Histological response of colorectal cancer liver metastases to chemotherapy
may be graded based on the extent of tumor regression. The knowledge about the effect of …