Leukocyte adhesion is of pivotal functional importance and this has resulted in extensive
research and rapid develoment in the field. Leukocyte adhesion involves members of three …

The relevance of extracellular magnesium in cellular immunity remains largely unknown.
Here, we show that the co-stimulatory cell-surface molecule LFA-1 requires magnesium to …

The sequestration of parasitized erythrocytes in the microvasculature of vital organs is
central to the pathogenesis of severe Plasmodium falciparum malaria. This process is …

We report that a subpopulation (10%) of the Mac-1 (CD1 1b/CD18) molecules on activated
neutrophils mediates adhesion to ICAM-1 and fibrinogen. We describe a novel mAb …

Integrin-ligand interactions are known to be dependent on divalent cations, although the
precise role of cations in ligand binding is still unclear. Using the interaction between α5β1 …

The monoclonal antibody 9EG7 has been previously found to recognize an epitope induced
by manganese on the integrin β 1 chain (Lenter, M., Uhlig, H., Hamann, A., Jeno, P., Imhof …

The very late activation antigens (VLA) or β1 integrins mediate cell attachment to different
extracellular matrix proteins and intercellular adhesions. The ligand binding activity of these …

Tissue inflammation induces rapid mobilization of antigen-charged dendritic cells (DCs),
which migrate to draining lymph nodes via afferent lymphatics to elicit the immune response …

THE co-ordinated function of effector and accessory cells in the immune system is assisted
by adhesion molecules on the cell surface that stabilize interactions between different cell …

T lymphocytes have an essential role in adaptive immunity and rely on the activation of
integrin lymphocyte function–associated antigen-1 (LFA-1) to mediate cell arrest and …