HLA-G: An important mediator of maternal-fetal immune-tolerance

B Zhuang, J Shang, Y Yao - Frontiers in Immunology, 2021 - frontiersin.org
Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

The protective role of maternal immunization in early life

B Cinicola, MG Conti, G Terrin, M Sgrulletti… - Frontiers in …, 2021 - frontiersin.org
With birth, the newborn is transferred from a quasi-sterile environment to the outside world.
At this time, the neonatal immune system is inexperienced and continuously subject to a …

Winds of change a tale of: asthma and microbiome

D Galeana-Cadena, IA Gómez-García… - Frontiers in …, 2023 - frontiersin.org
The role of the microbiome in asthma is highlighted, considering its influence on immune
responses and its connection to alterations in asthmatic patients. In this context, we review …

[HTML][HTML] Targeting interleukin-6 to treat neuromyelitis optica spectrum disorders: Implications from immunology, the FcRn pathway and clinical experience

J Sellner, HH Sitte, PS Rommer - Drug Discovery Today, 2021 - Elsevier
Neuromyelitis optica spectrum disorder (NMOSD) is a rare disease of the central nervous
system (CNS) that is associated with poor outcomes for patients. Until recently, when …

Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential

E Strachan, X Clemente-Casares, S Tsai - Frontiers in Immunology, 2023 - frontiersin.org
Maternal influences on the immune health and development of an infant begin in utero and
continue well into the postnatal period, shaping and educating the child's maturing immune …

Disturbances in the IgG Antibody Profile in HIV‐Exposed Uninfected Infants Associated with Maternal Factors

RT Camacho-Pacheco… - Journal of …, 2024 - Wiley Online Library
Over the last 20 years, the incidence of vertical HIV transmission has decreased from 25%–
42% to less than 1%. Although there are no signs of infection, the health of HIV‐exposed …

Immunomodulation of Antibody Glycosylation through the Placental Transfer

C Gao, Q Chen, X Hao, Q Wang - International Journal of Molecular …, 2023 - mdpi.com
Establishing an immune balance between the mother and fetus during gestation is crucial,
with the placenta acting as the epicenter of immune tolerance. The placental transfer of …

The Many Faces of Hemolysis

LS Cook - Journal of Infusion Nursing, 2023 - journals.lww.com
Hemolysis is a problem associated with a variety of red cell pathologies and physiologies
not limited to the transfusion of cells. Various pathways lead to the observed outcomes when …

[HTML][HTML] Ways in which the neonatal Fc-receptor is involved in autoimmunity

J Lamamy, P Boulard, G Brachet, S Tourlet… - Journal of Translational …, 2021 - Elsevier
Abstract Since the neonatal IgG Fc receptor (FcRn) was discovered, its role has evolved
from immunoglobulin recycling and biodistribution to antigen presentation and immune …

Maternal humoral factors modulate offspring gut immune homeostasis to mitigate diabetes development

E Strachan, L Pessoa-Soares, T Ju… - bioRxiv, 2024 - biorxiv.org
Environmental risk factors possess the potential to modulate the pathogenesis of type I
diabetes (T1D). Foremost among these factors are early life influences impacting the …