Pathophysiology and therapeutic approaches for spinal cord injury
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …
functions. Despite extensive research in the last decades, SCI continues to be a global …
Systemic inflammation in traumatic spinal cord injury
O Bloom, PE Herman, AM Spungen - Experimental neurology, 2020 - Elsevier
There are 17,730 new cases of spinal cord injury annually in the United States and up to 2.5
million individuals estimated to be living with chronic spinal cord injury (SCI)(Herman and …
million individuals estimated to be living with chronic spinal cord injury (SCI)(Herman and …
Immune response after central nervous system injury
AFM Salvador, J Kipnis - Seminars in immunology, 2022 - Elsevier
Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …
and they can lead to severely damaging consequences such as permanent disability and …
Selective inhibitors of medium-size S1′ pocket matrix metalloproteinases: a stepping stone of future drug discovery
Among various matrix metalloproteinases (MMPs), MMPs having medium-size S1′ pockets
are established as promising biomolecular targets for executing crucial roles in cancer …
are established as promising biomolecular targets for executing crucial roles in cancer …
[HTML][HTML] Models and approaches to comprehend and address glial inflammation following spinal cord injury
Spinal cord injury (SCI) culminates in chronic inflammation and glial scar formation driven by
the activation of microglia and astrocytes. Current anti-inflammatory strategies to treat glial …
the activation of microglia and astrocytes. Current anti-inflammatory strategies to treat glial …
[HTML][HTML] The non-canonical effects of heme oxygenase-1, a classical fighter against oxidative stress
J Wu, S Li, C Li, L Cui, J Ma, Y Hui - Redox biology, 2021 - Elsevier
The role of heme oxygenase-1 in resisting oxidative stress and cell protection has always
been a hot research topic. With the continuous deepening of research, in addition to directly …
been a hot research topic. With the continuous deepening of research, in addition to directly …
Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications
Y Jin, Y Song, J Lin, T Liu, G Li, B Lai, Y Gu… - Burns & …, 2023 - academic.oup.com
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete
loss of motor and sensory function. Massive neurons are damaged after the initial …
loss of motor and sensory function. Massive neurons are damaged after the initial …
Iron induces B cell pyroptosis through Tom20–Bax–caspase–gasdermin E signaling to promote inflammation post-spinal cord injury
C Wu, L Wang, S Chen, L Shi, M Liu, P Tu… - Journal of …, 2023 - Springer
Background Immune inflammatory responses play an important role in spinal cord injury
(SCI); however, the beneficial and detrimental effects remain controversial. Many studies …
(SCI); however, the beneficial and detrimental effects remain controversial. Many studies …
Advances in monitoring for acute spinal cord injury: a narrative review of current literature
Spinal cord injury (SCI) is a devastating condition that affects about 17,000 individuals every
year in the United States, with approximately 294,000 people living with the ramifications of …
year in the United States, with approximately 294,000 people living with the ramifications of …
[HTML][HTML] Role of CXCL10 in spinal cord injury
X Qiao, W Zhang, W Zhao - International journal of medical …, 2022 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) results in acute inflammatory responses and secondary damages,
including neuronal and glial cell death, axonal damage and demyelination, and blood-brain …
including neuronal and glial cell death, axonal damage and demyelination, and blood-brain …