Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Microglia are the resident immune cells and phagocytes of our central nervous system
(CNS). While most work has focused on the rapid and robust responses of microglia during …

Neuronal circuit assembly requires the fine balance between synapse formation and
elimination. Microglia, through the elimination of supernumerary synapses, have an …

Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …

Neuroinflammation is the response of the central nervous system (CNS) to disturbed
homeostasis and typifies all neurological diseases. The main reactive components of the …

The thalamus receives sensory input from different circuits in the periphery. How these
sensory channels are integrated at the level of single thalamic cells is not well understood …

Visual system circuitry, a canonical model system for the study of experience-dependent
development, matures before and following the onset of vision. Sensory experience or …

The advent of transgenic mice has made the developing retinogeniculate pathway a model
system for targeting potential mechanisms that underlie the refinement of sensory …

Experience-dependent plasticity in the mature visual system is widely considered to be
cortical. Using chronic two-photon Ca2+ imaging of thalamic afferents in layer 1 of binocular …

The dorsal lateral geniculate nucleus (dLGN) of the thalamus is the exclusive relay of retinal
information en route to the visual cortex. Although much of our understanding about dLGN …