Mood disorders are the most prevalent mental conditions encountered in psychiatric
practice. Numerous patients suffering from mood disorders present with treatment-resistant …

Bipolar disorder (BD) is a chronic and cyclic mental disorder, characterized by unusual
mood swings between mania/hypomania and depression, raising concern in both scientific …

Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …

Depressive disorders represent protean psychiatric illnesses with heterogeneous clinical
manifestations and a multitude of comorbidities leading to severe disability. In spite of …

Introduction Lumateperone is a novel antipsychotic medication that has recently received
approval by the United States Food and Drug Administration for treatment of major …

G protein‐coupled receptors (GPCRs) are intricately involved in the conversion of
extracellular feedback to intracellular responses. These specialized receptors possess a …

Introduction: The pharmacotherapeutic management of depression in patients with multiple
sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in …

Introduction Increased glutamate levels and electrolytic fluctuations have been observed in
acutely manic patients. Despite some efficacy of the non‐competitive NMDA receptor …

Background There is evidence of alterations in mitochondrial energy metabolism and
cerebral blood flow (CBF) in adults and youth with bipolar disorder (BD). Brain …

Bipolar disorder (BD), with a lifetime prevalence of about 2 per cent in the general
population and a recurrent course tending toward chronicity, represents one of the most …