Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Ageing is driven by a loss of cellular integrity. Given the major role of ubiquitin modifications
in cell function, here we assess the link between ubiquitination and ageing by quantifying …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

Stress granules (SGs) are highly conserved cytoplasmic condensates that assemble in
response to stress and contribute to maintaining protein homeostasis. These membraneless …

Ubiquitin signals play various roles in proteolytic and non-proteolytic functions. Ubiquitin
signals are recognized as targets of the ubiquitin–proteasome system and the autophagy …

In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as
Huntington's disease. Although plants express hundreds of polyQ-containing proteins, no …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …

Ubiquitin signaling is a sequence of events driving the fate of a protein based on the type of
ubiquitin modifications attached. In the case of neurodegenerative diseases, ubiquitin …