[HTML][HTML] The hallmarks of flavonoids in cancer

LGS Ponte, ICB Pavan, MCS Mancini, LGS da Silva… - Molecules, 2021 - mdpi.com
Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

S Mirzaei, S Saghari, F Bassiri, R Raesi… - Journal of cellular …, 2022 - Wiley Online Library
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

[HTML][HTML] Flavonoids as an effective sensitizer for anti-cancer therapy: Insights into multi-faceted mechanisms and applicability towards individualized patient profiles

A Liskova, M Samec, L Koklesova, A Brockmueller… - Epma Journal, 2021 - Springer
Cost-efficacy of currently applied treatments is an issue in overall cancer management
challenging healthcare and causing tremendous economic burden to societies around the …

[HTML][HTML] Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

P Kubatka, A Mazurakova, M Samec, L Koklesova… - Epma Journal, 2021 - Springer
Inflammation is an essential pillar of the immune defense. On the other hand, chronic
inflammation is considered a hallmark of cancer initiation and progression. Chronic …

[HTML][HTML] Date Palm Fruit (Phoenix dactylifera) and Its Promising Potential in Developing Functional Energy Bars: Review of Chemical, Nutritional, Functional, and …

H Barakat, HA Alfheeaid - Nutrients, 2023 - mdpi.com
Snack bars, known as energy bars, are widely consumed worldwide as highly nutritive on-
the-go products. Due to the date fruit's significant nutritional and functional characteristics, it …

Single‐nucleus RNA sequencing and spatial transcriptomics reveal the immunological microenvironment of cervical squamous cell carcinoma

Z Ou, S Lin, J Qiu, W Ding, P Ren, D Chen… - Advanced …, 2022 - Wiley Online Library
The effective treatment of advanced cervical cancer remains challenging. Herein, single‐
nucleus RNA sequencing (snRNA‐seq) and SpaTial enhanced resolution omics …

[HTML][HTML] An overview of the recent development of anticancer agents targeting the HIF-1 transcription factor

Y Shirai, CCT Chow, G Kambe, T Suwa, M Kobayashi… - Cancers, 2021 - mdpi.com
Simple Summary As hypoxia-inducible factor 1 (HIF-1) is recognized as a target for cancer
therapy, extensive efforts have been devoted to developing its inhibitors. We provide an …

[HTML][HTML] Flavonoids synergistically enhance the anti-glioblastoma effects of chemotherapeutic drugs

K Zhai, A Mazurakova, L Koklesova, P Kubatka… - Biomolecules, 2021 - mdpi.com
Flavonoids are polyphenolic plant secondary metabolites with pleiotropic biological
properties, including anti-cancer activities. These natural compounds have potential utility in …

HIF: a master regulator of nutrient availability and metabolic cross‐talk in the tumor microenvironment

R Missiaen, NP Lesner, MC Simon - The EMBO journal, 2023 - embopress.org
A role for hypoxia‐inducible factors (HIFs) in hypoxia‐dependent regulation of tumor cell
metabolism has been thoroughly investigated and covered in reviews. However, there is …

[HTML][HTML] Quercetin potential effects against SARS‐CoV‐2 infection and COVID‐19‐associated cancer progression by inhibiting mTOR and hypoxia‐inducible factor …

H Zalpoor, M Bakhtiyari, M Liaghat… - Phytotherapy …, 2022 - ncbi.nlm.nih.gov
Dear Editor, Globally, the coronavirus disease-2019 (COVID-19) pandemic has spread
rapidly, with millions of confirmed cases. Severe acute respiratory syndrome coronavirus 2 …