Discovery of cyclic peptide inhibitors targeting PD-L1 for cancer immunotherapy
Blockade of the interaction between programmed cell death ligand-1 (PD-L1) and its
receptor PD-1 has shown great success in cancer immunotherapy. Peptides possess unique …
receptor PD-1 has shown great success in cancer immunotherapy. Peptides possess unique …
Peptides and peptidomimetics as therapeutic agents for Covid‐19
The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) Covid‐19 pandemic
has caused high morbidity and mortality rates worldwide. Virus entry into cells can be …
has caused high morbidity and mortality rates worldwide. Virus entry into cells can be …
SARS-CoV-2 Omicron: Viral Evolution, Immune Evasion, and Alternative Durable Therapeutic Strategies
Since the SARS-CoV-2 Omicron virus has gained dominance worldwide, its continual
evolution with unpredictable mutations and patterns has revoked all authorized …
evolution with unpredictable mutations and patterns has revoked all authorized …
Examining sialic acid derivatives as potential inhibitors of SARS-CoV-2 spike protein receptor binding domain
Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has been the primary
reason behind the COVID-19 global pandemic which has affected millions of lives …
reason behind the COVID-19 global pandemic which has affected millions of lives …
Computational analysis of spike protein of SARS-CoV-2 (Omicron variant) for development of peptide-based therapeutics and diagnostics
In the last few years, the worldwide population has suffered from the SARS-CoV-2
pandemic. The WHO dashboard indicated that around 504,079,039 people were infected …
pandemic. The WHO dashboard indicated that around 504,079,039 people were infected …
Computational Design of Miniproteins as SARS-CoV-2 Therapeutic Inhibitors
B Jawad, P Adhikari, K Cheng, R Podgornik… - International Journal of …, 2022 - mdpi.com
A rational therapeutic strategy is urgently needed for combating SARS-CoV-2 infection. Viral
infection initiates when the SARS-CoV-2 receptor-binding domain (RBD) binds to the ACE2 …
infection initiates when the SARS-CoV-2 receptor-binding domain (RBD) binds to the ACE2 …
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2
MAJ Harman, SJ Stanway, H Scott… - Journal of Medicinal …, 2023 - ACS Publications
Angiotensin-converting enzyme 2 (ACE2) is a metalloprotease that cleaves angiotensin II, a
peptide substrate involved in the regulation of hypertension. Here, we identified a series of …
peptide substrate involved in the regulation of hypertension. Here, we identified a series of …
[HTML][HTML] SARS-CoV-2 pan-variant inhibitory peptides deter S1-ACE2 interaction and neutralize delta and omicron pseudoviruses
Approved neutralizing antibodies that target the prototype Spike are losing their potency
against the emerging variants of concern (VOCs) of SARS-CoV-2, particularly Omicron …
against the emerging variants of concern (VOCs) of SARS-CoV-2, particularly Omicron …
Will peptides help to stop COVID-19?
VG Krut', SA Chuvpilo, IV Astrakhantseva… - Biochemistry …, 2022 - Springer
Peptides are widely used for the diagnostics, prevention, and therapy of certain human
diseases. How useful can they be for the disease caused by the SARS-CoV-2 coronavirus …
diseases. How useful can they be for the disease caused by the SARS-CoV-2 coronavirus …
Screened Fv-Antibodies against the Angiotensin-Converting Enzyme 2 (ACE2) Receptor Neutralizing the Infection of SARS-CoV-2
J Jung, S Kwon, JS Sung, HE Bae… - ACS Pharmacology & …, 2024 - ACS Publications
For the prevention of SARS-CoV-2 infection, four Fv-antibodies with binding affinity for the
ACE2 receptor were screened from an Fv-antibody library. The screened Fv-antibodies were …
ACE2 receptor were screened from an Fv-antibody library. The screened Fv-antibodies were …