Stem cell therapy for human neurodegenerative disorders–how to make it work

O Lindvall, Z Kokaia, A Martinez-Serrano - Nature medicine, 2004 - nature.com
Recent progress shows that neurons suitable for transplantation can be generated from
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …

Stem cell‐based cell therapy in neurological diseases: a review

SU Kim, J De Vellis - Journal of neuroscience research, 2009 - Wiley Online Library
Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …

How to make a mesodiencephalic dopaminergic neuron

MP Smidt, JPH Burbach - Nature Reviews Neuroscience, 2007 - nature.com
Dopaminergic neurons located in the ventral mesodiencephalon are essential for the control
of voluntary movement and the regulation of emotion, and are severely affected in …

Neural stem cell‐based treatment for neurodegenerative diseases

SU Kim, HJ Lee, YB Kim - Neuropathology, 2013 - Wiley Online Library
Human neurodegenrative diseases such as P arkinson's disease (PD), H untington's
disease (HD), amyotrophic lateral sclerosis (ALS) and A lzheimer's disease (AD) are caused …

Neural stem cell therapy—Brief review

C Grochowski, E Radzikowska… - Clinical neurology and …, 2018 - Elsevier
Adult mammalian neural stem cells are unique because of their properties, such as
differentiation capacity, self-renewal, quiescence, and also because they exist in specific …

In vitro and in vivo analyses of human embryonic stem cell‐derived dopamine neurons

CH Park, YK Minn, JY Lee, DH Choi… - Journal of …, 2005 - Wiley Online Library
Human embryonic stem (hES) cells, due to their capacity of multipotency and self‐renewal,
may serve as a valuable experimental tool for human developmental biology and may …

Identification of embryonic stem cell–derived midbrain dopaminergic neurons for engraftment

YM Ganat, EL Calder, S Kriks… - The Journal of …, 2012 - Am Soc Clin Investig
Embryonic stem cells (ESCs) represent a promising source of midbrain dopaminergic (DA)
neurons for applications in Parkinson disease. However, ESC-based transplantation …

Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia

L Wei, L Cui, BJ Snider, M Rivkin, SY Steven… - Neurobiology of …, 2005 - Elsevier
The study tested the hypothesis that transplantation of embryonic stem (ES) cells into rat
cortex after a severe focal ischemia would promote structural repair and functional recovery …

Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease

JR Richardson, WM Caudle, M Wang… - The FASEB …, 2006 - Wiley Online Library
Exposure to pesticides has been suggested to increase the risk of Parkinson's disease (PD),
but the mechanisms responsible for this association are not clear. Here, we report that …

Bcl-x is required for proper development of the mouse substantia nigra

JM Savitt, SS Jang, W Mu, VL Dawson… - Journal of …, 2005 - Soc Neuroscience
Recent findings have uncovered a role for the Bcl-x gene in the survival of dopaminergic
neurons. The exact nature of this role has been difficult to examine because of the …