Making sense of astrocytic calcium signals—from acquisition to interpretation
A Semyanov, C Henneberger, A Agarwal - Nature Reviews …, 2020 - nature.com
Astrocytes functionally interact with neurons and with other brain cells. Although not
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
electrically excitable, astrocytes display a complex repertoire of intracellular Ca2+ signalling …
Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
Distinct fission signatures predict mitochondrial degradation or biogenesis
Mitochondrial fission is a highly regulated process that, when disrupted, can alter
metabolism, proliferation and apoptosis,–. Dysregulation has been linked to …
metabolism, proliferation and apoptosis,–. Dysregulation has been linked to …
The growing and glowing toolbox of fluorescent and photoactive proteins
Over the past 20 years, protein engineering has been extensively used to improve and
modify the fundamental properties of fluorescent proteins (FPs) with the goal of adapting …
modify the fundamental properties of fluorescent proteins (FPs) with the goal of adapting …
ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons
Y Hirabayashi, SK Kwon, H Paek, WM Pernice… - Science, 2017 - science.org
Interfaces between organelles are emerging as critical platforms for many biological
responses in eukaryotic cells. In yeast, the ERMES complex is an endoplasmic reticulum …
responses in eukaryotic cells. In yeast, the ERMES complex is an endoplasmic reticulum …
Optogenetic tools for subcellular applications in neuroscience
The ability to study cellular physiology using photosensitive, genetically encoded molecules
has profoundly transformed neuroscience. The modern optogenetic toolbox includes …
has profoundly transformed neuroscience. The modern optogenetic toolbox includes …
Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons
E Zampese, DL Wokosin, P Gonzalez-Rodriguez… - Science …, 2022 - science.org
How do neurons match generation of adenosine triphosphate by mitochondria to the
bioenergetic demands of regenerative activity? Although the subject of speculation, this …
bioenergetic demands of regenerative activity? Although the subject of speculation, this …
Calcium channel ITPR2 and mitochondria–ER contacts promote cellular senescence and aging
DV Ziegler, D Vindrieux, D Goehrig, S Jaber… - Nature …, 2021 - nature.com
Cellular senescence is induced by stresses and results in a stable proliferation arrest
accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging …
accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging …
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune
bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the …
bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the …
Contact-ID, a tool for profiling organelle contact sites, reveals regulatory proteins of mitochondrial-associated membrane formation
The mitochondria-associated membrane (MAM) has emerged as a cellular signaling hub
regulating various cellular processes. However, its molecular components remain unclear …
regulating various cellular processes. However, its molecular components remain unclear …