Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Before a lead compound goes through a clinical trial, preclinical studies utilize two‐
dimensional (2D) in vitro models and animal models to study the pharmacodynamics and …

Induction of intestinal drug metabolizing enzymes can complicate the development of new
drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in …

The physiological environment of the intestine is characterized by its variegated
composition, numerous functions and unique dynamic conditions, making it challenging to …

Mucositis research and treatment are a rapidly evolving field providing constant new
avenues of research and potential therapies. The MASCC/ISOO Mucositis Study Group …

ABSTRACT The 3Rs–Replacement, Reduction and Refinement–are embedded into the
legislation and guidelines governing the ethics of animal use in experiments. Here, we …

Cancer immunotherapy has revolutionized the way tumors are treated. Nevertheless,
efficient and robust testing platforms are still missing, including clinically relevant human ex …

Glioblastoma (GBM) is a severe malignant brain cancer with poor overall survival.
Conventional intervention remains dismal to prevent recurrence and deterioration of GBM …

The Caco-2 monolayer is the most widely used in vitro model of the human intestinal
mucosa to study absorption. However, models lack communication from other cells present …

Simple Summary Colorectal cancer is one of the most frequent and lethal types of cancer.
Despite advances in recent decades, our knowledge of this disease is still limited, and novel …