Diagnostic accuracy of immunohistochemistry for mismatch repair proteins as surrogate of microsatellite instability molecular testing in endometrial cancer
Microsatellite instability (MSI) defines one of the four molecular groups of endometrial
carcinoma identified by The Cancer Genome Atlas (TCGA). Immunohistochemistry for …
carcinoma identified by The Cancer Genome Atlas (TCGA). Immunohistochemistry for …
The role of immunohistochemistry markers in endometrial cancer with mismatch repair deficiency: a systematic review
Simple Summary Identification of mismatch repair-deficient tumors (MMRd), which occur in
up to 30% of all endometrial cancers (EC), has become unavoidable for therapeutic …
up to 30% of all endometrial cancers (EC), has become unavoidable for therapeutic …
Noninvasive detection of microsatellite instability in patients with endometrial cancer
C Casas‐Arozamena, CP Moiola, A Vilar… - … Journal of Cancer, 2023 - Wiley Online Library
The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the
microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates …
microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates …
Histological and somatic mutational profiles of mismatch repair deficient endometrial tumours of different aetiologies
NAJ Ryan, TDJ Walker, J Bolton, N Ter Haar… - Cancers, 2021 - mdpi.com
Simple Summary Endometrial cancers can arise due to an error in DNA mending known as
mismatch repair. This can happen because of an error in the cancer itself (somatic) or due to …
mismatch repair. This can happen because of an error in the cancer itself (somatic) or due to …
Germline SMARCA4 Deletion as a Driver of Uterine Cancer: An Atypical Presentation
A Navitski, DH Al-Rawi, V Makker, B Weigelt… - JCO Precision …, 2022 - ascopubs.org
The SMARCA4 gene codes for a transcription activator protein of the switch/sucrose-
nonfermenting (SWI/SNF) adenosine triphosphate (ATP)–dependent nucleosome …
nonfermenting (SWI/SNF) adenosine triphosphate (ATP)–dependent nucleosome …
HNRNPCL1, PRAMEF1, CFAP74, and DFFB: Common Potential Biomarkers for Sporadic and Suspected Lynch Syndrome Endometrial Cancer
Y Gao, X Zhang, T Wang, Y Zhang… - Cancer management …, 2020 - Taylor & Francis
Purpose To investigate the genes of patients with sporadic endometrial cancer (EC) and
suspected Lynch syndrome (LS)-related EC in the Chinese population. Identification of …
suspected Lynch syndrome (LS)-related EC in the Chinese population. Identification of …
A Durable Response to Pembrolizumab in a Patient with Uterine Serous Carcinoma and Lynch Syndrome due to the MSH6 Germline Mutation
KT Danley, K Schmitz, R Ghai, JS Sclamberg… - The …, 2021 - academic.oup.com
Pembrolizumab, a programmed death 1 ligand (PD-1) checkpoint inhibitor, has elicited
responses in mismatch repair (MMR)–deficient advanced solid tumors, leading to its …
responses in mismatch repair (MMR)–deficient advanced solid tumors, leading to its …
Investigation into the early pathogenesis of lynch syndrome associated endometrial cancer
MK DeGrood - 2022 - open.library.ubc.ca
Endometrial cancer is the most common gynecologic malignancy in Canada with increasing
rates of both incidence and mortality. Historically, histopathological subtyping of endometrial …
rates of both incidence and mortality. Historically, histopathological subtyping of endometrial …