In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family
members regulate the release of proteins from the space between the mitochondrial inner …

Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating
transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate. The activity of …

The realization that alterations in inhibitor of apoptosis (IAP) proteins are found in many
types of human cancer and are associated with chemoresistance, disease progression and …

Caspases, which are the executioners of apoptosis, comprise two distinct classes, the
initiators and the effectors. Although general structural features are shared between the …

Cell proliferation, cell death, and pattern formation are coordinated in animal development.
Although many proteins that control cell proliferation and apoptosis have been identified, the …

The cellular stress response corresponds to the molecular changes that a cell undergoes in
response to various environmental stimuli. It induces drastic changes in the regulation of …

The'inhibitor of apoptosis'(IAP) gene family, which was discovered less than a decade ago,
encodes a group of structurally related proteins that, in addition to their ability to suppress …

The coordination between cell proliferation and cell death is essential to maintain
homeostasis within multicellular organisms. The mechanisms underlying this regulation are …