Current progress in the derivation and therapeutic application of neural stem cells

Y Tang, P Yu, L Cheng - Cell death & disease, 2017 - nature.com
Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on
NSC transplantation is a promising tool for the treatment of nervous system diseases …

How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

JPA Ioannidis, BYS Kim, A Trounson - Nature biomedical engineering, 2018 - nature.com
The clinical translation of promising products, technologies and interventions from the
disciplines of nanomedicine and cell therapy has been slow and inefficient. In part …

[HTML][HTML] A review of the pathology and treatment of TBI and PTSD

M Monsour, D Ebedes, CV Borlongan - Experimental neurology, 2022 - Elsevier
This literature review focuses on the underlying pathophysiology of TBI and PTSD
symptoms, while also examining the plethora of stem cell treatment options to ameliorate …

[HTML][HTML] The neural stem cell secretome and its role in brain repair

CM Willis, AM Nicaise, L Peruzzotti-Jametti, S Pluchino - Brain research, 2020 - Elsevier
Compelling evidence from experimental animal disease models and early-phase clinical
trials identifies the transplantation of neural progenitor/stem cells (NSCs) as a viable path …

[HTML][HTML] Neural stem cells for Parkinson's disease management: Challenges, nanobased support, and prospects

T Oz, A Kaushik, M Kujawska - World Journal of Stem Cells, 2023 - ncbi.nlm.nih.gov
Abstract Parkinson's disease (PD), characterized by loss of nigrostriatal dopaminergic
neurons, is one of the most predominant neurodegenerative diseases affecting the elderly …

Challenges in the clinical advancement of cell therapies for Parkinson's disease

S Skidmore, RA Barker - Nature biomedical engineering, 2023 - nature.com
Cell therapies as potential treatments for Parkinson's disease first gained traction in the
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …

Dysfunction in brain-derived neurotrophic factor signaling pathway and susceptibility to schizophrenia, Parkinson's and Alzheimer's diseases

A Mohammadi, VG Amooeian… - Current gene …, 2018 - ingentaconnect.com
Brain-Derived Neurotrophic Factor (BDNF) is a dominant neurotrophic factor in the brain
which plays a crucial role in differentiation, regeneration and plasticity mechanisms. Binding …

Cell therapy for Parkinson's disease

T Yasuhara, M Kameda, T Sasaki, N Tajiri… - Cell …, 2017 - journals.sagepub.com
Cell therapy for Parkinson's disease (PD) began in 1979 with the transplantation of fetal rat
dopamine-containing neurons that improved motor abnormalities in the PD rat model with …

Human clinical-grade parthenogenetic ESC-derived dopaminergic neurons recover locomotive defects of nonhuman primate models of Parkinson's disease

YK Wang, WW Zhu, MH Wu, YH Wu, ZX Liu, LM Liang… - Stem cell reports, 2018 - cell.com
Clinical application of stem cell derivatives requires clinical-grade cells and sufficient
preclinical proof of safety and efficacy, preferably in primates. We previously successfully …

Low-temperature 3D-printed collagen/chitosan scaffolds loaded with exosomes derived from neural stem cells pretreated with insulin growth factor-1 enhance neural …

XY Liu, YH Feng, QB Feng, JY Zhang… - Neural Regeneration …, 2023 - journals.lww.com
There are various clinical treatments for traumatic brain injury, including surgery, drug
therapy, and rehabilitation therapy; however, the therapeutic effects are limited. Scaffolds …