Current progress in the derivation and therapeutic application of neural stem cells
Y Tang, P Yu, L Cheng - Cell death & disease, 2017 - nature.com
Neural stem cells (NSCs) have a unique role in neural regeneration. Cell therapy based on
NSC transplantation is a promising tool for the treatment of nervous system diseases …
NSC transplantation is a promising tool for the treatment of nervous system diseases …
How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation
The clinical translation of promising products, technologies and interventions from the
disciplines of nanomedicine and cell therapy has been slow and inefficient. In part …
disciplines of nanomedicine and cell therapy has been slow and inefficient. In part …
[HTML][HTML] A review of the pathology and treatment of TBI and PTSD
This literature review focuses on the underlying pathophysiology of TBI and PTSD
symptoms, while also examining the plethora of stem cell treatment options to ameliorate …
symptoms, while also examining the plethora of stem cell treatment options to ameliorate …
[HTML][HTML] The neural stem cell secretome and its role in brain repair
Compelling evidence from experimental animal disease models and early-phase clinical
trials identifies the transplantation of neural progenitor/stem cells (NSCs) as a viable path …
trials identifies the transplantation of neural progenitor/stem cells (NSCs) as a viable path …
[HTML][HTML] Neural stem cells for Parkinson's disease management: Challenges, nanobased support, and prospects
Abstract Parkinson's disease (PD), characterized by loss of nigrostriatal dopaminergic
neurons, is one of the most predominant neurodegenerative diseases affecting the elderly …
neurons, is one of the most predominant neurodegenerative diseases affecting the elderly …
Challenges in the clinical advancement of cell therapies for Parkinson's disease
S Skidmore, RA Barker - Nature biomedical engineering, 2023 - nature.com
Cell therapies as potential treatments for Parkinson's disease first gained traction in the
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …
1980s, owing to the clinical success of trials that used transplants of foetal midbrain …
Dysfunction in brain-derived neurotrophic factor signaling pathway and susceptibility to schizophrenia, Parkinson's and Alzheimer's diseases
A Mohammadi, VG Amooeian… - Current gene …, 2018 - ingentaconnect.com
Brain-Derived Neurotrophic Factor (BDNF) is a dominant neurotrophic factor in the brain
which plays a crucial role in differentiation, regeneration and plasticity mechanisms. Binding …
which plays a crucial role in differentiation, regeneration and plasticity mechanisms. Binding …
Cell therapy for Parkinson's disease
T Yasuhara, M Kameda, T Sasaki, N Tajiri… - Cell …, 2017 - journals.sagepub.com
Cell therapy for Parkinson's disease (PD) began in 1979 with the transplantation of fetal rat
dopamine-containing neurons that improved motor abnormalities in the PD rat model with …
dopamine-containing neurons that improved motor abnormalities in the PD rat model with …
Human clinical-grade parthenogenetic ESC-derived dopaminergic neurons recover locomotive defects of nonhuman primate models of Parkinson's disease
YK Wang, WW Zhu, MH Wu, YH Wu, ZX Liu, LM Liang… - Stem cell reports, 2018 - cell.com
Clinical application of stem cell derivatives requires clinical-grade cells and sufficient
preclinical proof of safety and efficacy, preferably in primates. We previously successfully …
preclinical proof of safety and efficacy, preferably in primates. We previously successfully …
Low-temperature 3D-printed collagen/chitosan scaffolds loaded with exosomes derived from neural stem cells pretreated with insulin growth factor-1 enhance neural …
XY Liu, YH Feng, QB Feng, JY Zhang… - Neural Regeneration …, 2023 - journals.lww.com
There are various clinical treatments for traumatic brain injury, including surgery, drug
therapy, and rehabilitation therapy; however, the therapeutic effects are limited. Scaffolds …
therapy, and rehabilitation therapy; however, the therapeutic effects are limited. Scaffolds …