Epigenetic regulation in breast cancer: Insights on epidrugs

A Kim, K Mo, H Kwon, S Choe, M Park, W Kwak… - Epigenomes, 2023 - mdpi.com
Breast cancer remains a common cause of cancer-related death in women. Therefore,
further studies are necessary for the comprehension of breast cancer and the revolution of …

Epigenetics in congenital heart disease

G Wang, B Wang, P Yang - Journal of the American Heart …, 2022 - Am Heart Assoc
Embryonic heart development is an intricate process that mainly involves morphogens,
transcription factors, and cardiac genes. The precise spatiotemporal expression of these …

The role of selected epigenetic pathways in cardiovascular diseases as a potential therapeutic target

A Wołowiec, Ł Wołowiec, G Grześk, A Jaśniak… - International Journal of …, 2023 - mdpi.com
Epigenetics is a rapidly developing science that has gained a lot of interest in recent years
due to the correlation between characteristic epigenetic marks and cardiovascular diseases …

Epigenetics and congenital heart diseases

L Linglart, D Bonnet - Journal of Cardiovascular Development and …, 2022 - mdpi.com
Congenital heart disease (CHD) is a frequent occurrence, with a prevalence rate of almost
1% in the general population. However, the pathophysiology of the anomalous heart …

Nuclear control of vascular smooth muscle cell plasticity during vascular remodeling

IA Ahmed, M Liu, D Gomez - The American Journal of Pathology, 2024 - Elsevier
Control of vascular smooth muscle cell (SMC) gene expression is an essential process for
establishing and maintaining lineage identity, contractility, and plasticity. Most mechanisms …

Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation

KX Li, JR Li, SJ Zuo, X Li, XT Chen, PY Xiao, HT Li… - Clinical …, 2024 - Springer
Background Congenital heart disease (CHD) is a prevalent congenital cardiac malformation,
which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic …

Reprogramming of DNA methylation patterns mediates perfluorooctane sulfonate-induced fetal cardiac dysplasia

M Qiu, J Chen, M Liu, Y Shi, Z Nie, G Dong, X Li… - Science of The Total …, 2024 - Elsevier
Prenatal exposure to perfluorooctane sulfonate (PFOS) is associated with adverse health
effects, including congenital heart disease, yet the underlying mechanisms remain elusive …

Epigenome rewiring in human pluripotent stem cells

J Yan, D Huangfu - Trends in cell biology, 2022 - cell.com
The epigenome plays a crucial role in modulating the activity of regulatory elements, thereby
orchestrating diverse transcriptional programs during embryonic development. Human (h) …

Epigenetics in diabetic cardiomyopathy

X Ma, S Mei, Q Wuyun, L Zhou, D Sun, J Yan - Clinical Epigenetics, 2024 - Springer
Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the
health of patients with diabetes. The intricate pathological mechanisms of DCM cause …

Epigenetic regulation of heart failure

M Deogharia, P Gurha - Current Opinion in Cardiology, 2024 - journals.lww.com
Epigenetic modifications provide a mechanism for responding to stress and environmental
variation, enabling reactions to both external and internal stimuli, and their dysregulation …