Harnessing the therapeutic potential of the stem cell secretome in neonatal diseases

S Tung, E Delavogia, A Fernandez-Gonzalez… - Seminars in …, 2023 - Elsevier
Preterm birth and intrapartum related complications account for a substantial amount of
mortality and morbidity in the neonatal period despite significant advancements in neonatal …

Mesenchymal stromal cell-derived extracellular vesicles for neonatal lung disease: tiny particles, major promise, rigorous requirements for clinical translation

F Lesage, B Thébaud - Cells, 2022 - mdpi.com
Extreme preterm birth disrupts late lung development and puts newborns at risk of
developing chronic lung disease, known as bronchopulmonary dysplasia (BPD). BPD can …

Stem cell-derived extracellular vesicles: a potential intervention for Bronchopulmonary Dysplasia

H Saneh, H Wanczyk, J Walker, C Finck - Pediatric Research, 2024 - nature.com
Despite advances in neonatal care, the incidence of Bronchopulmonary Dysplasia (BPD)
remains high among extreme preterm infants. The pathogenesis of BPD is multifactorial, with …

[HTML][HTML] Extracellular vesicles from mesenchymal umbilical cord cells exert protection against oxidative stress and fibrosis in a rat model of bronchopulmonary …

P Bisaccia, F Magarotto, S D'Agostino… - Stem Cells …, 2024 - academic.oup.com
Oxidative stress and fibrosis are important stress responses that characterize
bronchopulmonary dysplasia (BPD), a disease for which only a therapy but not a cure has …

Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway

J Shi, S Song, Y Wang, K Wu, G Liang, A Wang… - International …, 2024 - Elsevier
Background Alveolar epithelial cell (AEC) ferroptosis contributes to the progression of acute
lung injury (ALI). Esketamine (ESK) is a new clinical sedative, anesthetic, and analgesic …

Effectiveness of extracellular vesicles derived from hiPSCs in repairing hyperoxia-induced injury in a fetal murine lung explant model

H Saneh, H Wanczyk, J Walker, C Finck - Stem Cell Research & Therapy, 2024 - Springer
Background Despite advances in neonatal care, the incidence of Bronchopulmonary
Dysplasia (BPD) remains high among preterm infants. Human induced pluripotent stem cells …

Stem cell therapies for neonatal lung diseases: Are we there yet?

B Thébaud - Seminars in Perinatology, 2023 - Elsevier
Lung diseases are a main cause of mortality and morbidity in neonates. Despite major
breakthroughs, therapies remain supportive and, in some instances, contribute to lung …

Prophylactic administration of mesenchymal stromal cells does not prevent arrested lung development in extremely premature-born non-human primates

MA Möbius, SR Seidner, DC McCurnin… - Stem Cells …, 2023 - academic.oup.com
Premature birth is a leading cause of childhood morbidity and mortality and often followed
by an arrest of postnatal lung development called bronchopulmonary dysplasia. Therapies …

Perinatal origins of bronchopulmonary dysplasia—deciphering normal and impaired lung development cell by cell

I Mižíková, B Thébaud - Molecular and Cellular Pediatrics, 2023 - Springer
Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence
of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD …

Therapeutic potential of extracellular vesicles derived from human amniotic epithelial cells for perinatal cerebral and pulmonary injury.

N Kumar, HR Bidkhori, T Yawno, R Lim… - Stem Cells …, 2024 - academic.oup.com
Lung and brain injury that occurs during the perinatal period leads to lifelong disability and
is often driven and/or exacerbated by inflammation. Human amniotic epithelial cells (hAEC) …