Harnessing the therapeutic potential of the stem cell secretome in neonatal diseases
S Tung, E Delavogia, A Fernandez-Gonzalez… - Seminars in …, 2023 - Elsevier
Preterm birth and intrapartum related complications account for a substantial amount of
mortality and morbidity in the neonatal period despite significant advancements in neonatal …
mortality and morbidity in the neonatal period despite significant advancements in neonatal …
Mesenchymal stromal cell-derived extracellular vesicles for neonatal lung disease: tiny particles, major promise, rigorous requirements for clinical translation
F Lesage, B Thébaud - Cells, 2022 - mdpi.com
Extreme preterm birth disrupts late lung development and puts newborns at risk of
developing chronic lung disease, known as bronchopulmonary dysplasia (BPD). BPD can …
developing chronic lung disease, known as bronchopulmonary dysplasia (BPD). BPD can …
Stem cell-derived extracellular vesicles: a potential intervention for Bronchopulmonary Dysplasia
Despite advances in neonatal care, the incidence of Bronchopulmonary Dysplasia (BPD)
remains high among extreme preterm infants. The pathogenesis of BPD is multifactorial, with …
remains high among extreme preterm infants. The pathogenesis of BPD is multifactorial, with …
[HTML][HTML] Extracellular vesicles from mesenchymal umbilical cord cells exert protection against oxidative stress and fibrosis in a rat model of bronchopulmonary …
P Bisaccia, F Magarotto, S D'Agostino… - Stem Cells …, 2024 - academic.oup.com
Oxidative stress and fibrosis are important stress responses that characterize
bronchopulmonary dysplasia (BPD), a disease for which only a therapy but not a cure has …
bronchopulmonary dysplasia (BPD), a disease for which only a therapy but not a cure has …
Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway
J Shi, S Song, Y Wang, K Wu, G Liang, A Wang… - International …, 2024 - Elsevier
Background Alveolar epithelial cell (AEC) ferroptosis contributes to the progression of acute
lung injury (ALI). Esketamine (ESK) is a new clinical sedative, anesthetic, and analgesic …
lung injury (ALI). Esketamine (ESK) is a new clinical sedative, anesthetic, and analgesic …
Effectiveness of extracellular vesicles derived from hiPSCs in repairing hyperoxia-induced injury in a fetal murine lung explant model
Background Despite advances in neonatal care, the incidence of Bronchopulmonary
Dysplasia (BPD) remains high among preterm infants. Human induced pluripotent stem cells …
Dysplasia (BPD) remains high among preterm infants. Human induced pluripotent stem cells …
Stem cell therapies for neonatal lung diseases: Are we there yet?
B Thébaud - Seminars in Perinatology, 2023 - Elsevier
Lung diseases are a main cause of mortality and morbidity in neonates. Despite major
breakthroughs, therapies remain supportive and, in some instances, contribute to lung …
breakthroughs, therapies remain supportive and, in some instances, contribute to lung …
Prophylactic administration of mesenchymal stromal cells does not prevent arrested lung development in extremely premature-born non-human primates
MA Möbius, SR Seidner, DC McCurnin… - Stem Cells …, 2023 - academic.oup.com
Premature birth is a leading cause of childhood morbidity and mortality and often followed
by an arrest of postnatal lung development called bronchopulmonary dysplasia. Therapies …
by an arrest of postnatal lung development called bronchopulmonary dysplasia. Therapies …
Perinatal origins of bronchopulmonary dysplasia—deciphering normal and impaired lung development cell by cell
I Mižíková, B Thébaud - Molecular and Cellular Pediatrics, 2023 - Springer
Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence
of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD …
of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD …
Therapeutic potential of extracellular vesicles derived from human amniotic epithelial cells for perinatal cerebral and pulmonary injury.
Lung and brain injury that occurs during the perinatal period leads to lifelong disability and
is often driven and/or exacerbated by inflammation. Human amniotic epithelial cells (hAEC) …
is often driven and/or exacerbated by inflammation. Human amniotic epithelial cells (hAEC) …