Progress of immunotherapies in gestational trophoblastic neoplasms

T Wang, W Guo, X Ren, F Lang, Y Ma, C Qiu… - Journal of Cancer …, 2023 - Springer
Background Different from other malignant gynecologic tumors, gestational trophoblastic
neoplasms (GTNs) exhibit an exceptionally high cure rate primarily through …

Harnessing the potential of HLA-G in cancer therapy: advances, challenges, and prospects

S Wang, J Wang, Y Xia, L Zhang, Y Jiang, M Liu… - Journal of Translational …, 2024 - Springer
Immune checkpoint blockades have been prized in circumventing and ablating the
impediments posed by immunosuppressive receptors, reaching an exciting juncture to be an …

Curing Psoriasis

SM Lwin, S Azrielant, J He, CEM Griffiths - Journal of Investigative …, 2024 - Elsevier
As medicine advances, cures are being found for diseases that were previously considered
incurable, as is the case for some types of cancer. Traditionally, the term cure is reserved for …

The human leukocyte antigen G as an immune escape mechanism and novel therapeutic target in urological tumors

S Jasinski-Bergner, M Eckstein, H Taubert… - Frontiers in …, 2022 - frontiersin.org
The non-classical human leukocyte antigen G (HLA-G) is a potent regulatory protein
involved in the induction of immunological tolerance. This is based on the binding of …

HLA-G neo-expression modifies genetic programs governing tumor cell lines

D Tronik-Le Roux, M Daouya, I Poras… - Cancer Immunology …, 2024 - Springer
The development of immunotherapies has proved to be clinically encouraging to re-
establish the immune function modified by the expression of immune inhibitory molecules in …

Current application and future perspective of CRISPR/cas9 gene editing system mediated immune checkpoint for liver cancer treatment

LW Tong, YS Hu, SJ Yu, CL Li, JW Shao - Nanotechnology, 2024 - iopscience.iop.org
Liver cancer, which is well-known to us as one of human most prevalent malignancies
across the globe, poses a significant risk to live condition and life safety of individuals in …

[HTML][HTML] Application of a JEG-3 organoid model to study HLA-G function in the trophoblast

BM Zhuang, DD Cao, XF Liu, L Wang, XL Lin… - Frontiers in …, 2023 - frontiersin.org
The human placenta is a unique temporary organ with a mysterious immune tolerance. The
formation of trophoblast organoids has advanced the study of placental development. HLA …

HLA-G: A Novel Immune Checkpoint for Solid Cancer Immunotherapy

A Lin, WH Yan - Handbook of Cancer and Immunology, 2023 - Springer
Background: The distribution of human leukocyte antigen-G (HLA-G) is limited in
physiological situations. Functionally, HLA-G is an important immunotolerant that …