Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and
enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They …

Apical–basal polarity is essential for the formation and function of epithelial tissues, whereas
loss of polarity is a hallmark of tumours. Studies in Drosophila have identified conserved …

The establishment of an apical–basal axis of polarity is essential for the organization and
functioning of epithelial cells. Polarization of epithelial cells is orchestrated by a network of …

The formation of distinct subdomains of the cell surface is crucial for multicellular organism
development. The most striking example of this is apical‐basal polarization. What is much …

Establishing and maintaining cell polarity are dynamic processes that necessitate
complicated but highly regulated protein interactions. Phosphorylation is a powerful …

The Crumbs complex has prominent roles in the control of apical cell polarity, in the coupling
of cell density sensing to downstream cell signaling pathways, and in regulating junctional …

Once considered science fiction, gene therapy is rapidly becoming scientific reality, targeting
a growing number of the approximately 250 genes linked to hereditary retinal disorders such …

Abstract Crumbs (Crb in Drosophila; CRB1-3 in mammals) is a transmembrane determinant
of epithelial cell polarity and a regulator of Hippo signalling. Crb is normally localized to …