[HTML][HTML] Seventy years of Chlamydia vaccine research–limitations of the past and directions for the future

S Phillips, BL Quigley, P Timms - Frontiers in microbiology, 2019 - frontiersin.org
Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of
animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only …

Engineering of obligate intracellular bacteria: progress, challenges and paradigms

EE McClure, ASO Chávez, DK Shaw… - Nature Reviews …, 2017 - nature.com
It is estimated that approximately one billion people are at risk of infection with obligate
intracellular bacteria, but little is known about the underlying mechanisms that govern their …

Diversity of vaginal microbiome and metabolome during genital infections

C Ceccarani, C Foschi, C Parolin, A D'Antuono… - Scientific reports, 2019 - nature.com
We characterized the vaginal ecosystem during common infections of the female genital
tract, as vulvovaginal candidiasis (VVC, n= 18) and Chlamydia trachomatis infection (CT, n …

Chlamydia trachomatis as a Current Health Problem: Challenges and Opportunities

R Rodrigues, C Sousa, N Vale - Diagnostics, 2022 - mdpi.com
Chlamydia is one of the most common sexually transmitted bacterial infections (STIs)
worldwide. It is caused by Chlamydia trachomatis (CT), which is an obligate intracellular …

Microbiota and human reproduction: the case of male infertility

R Tomaiuolo, I Veneruso, F Cariati, V D'Argenio - High-throughput, 2020 - mdpi.com
The increasing interest in metagenomics is enhancing our knowledge regarding the
composition and role of the microbiota in human physiology and pathology. Indeed …

Relation between Chlamydia trachomatis infection and pelvic inflammatory disease, ectopic pregnancy and tubal factor infertility in a Dutch cohort of women …

BM Hoenderboom, BHB Van Benthem… - Sexually transmitted …, 2019 - sti.bmj.com
Objectives A better understanding of Chlamydia trachomatis infection (chlamydia)–related
sequelae can provide a framework for effective chlamydia control strategies. The objective of …

Molecular pathogenesis of Chlamydia trachomatis

B Jury, C Fleming, WM Huston… - Frontiers in Cellular and …, 2023 - frontiersin.org
Chlamydia trachomatis is a strict intracellular human pathogen. It is the main bacterial cause
of sexually transmitted infections and the etiologic agent of trachoma, which is the leading …

Lactobacillus crispatus BC5 Interferes With Chlamydia trachomatis Infectivity Through Integrin Modulation in Cervical Cells

C Parolin, G Frisco, C Foschi, B Giordani… - Frontiers in …, 2018 - frontiersin.org
Lactobacilli play a crucial role in maintaining the ecological equilibrium of the vaginal niche,
preventing the colonization of exogenous microorganisms. Although many studies have …

Chlamydia trachomatis genital tract infections: when host immune response and the microbiome collide

N Ziklo, WM Huston, JS Hocking, P Timms - Trends in microbiology, 2016 - cell.com
Genital infections with Chlamydia trachomatis continue to be a major health problem
worldwide. While some individuals clear their infection (presumed to be the result of an …

Manipulation of host cell organelles by intracellular pathogens

TO Omotade, CR Roy - Microbiology spectrum, 2019 - Am Soc Microbiol
In this article, we explore the unique adaptations of intracellular bacterial pathogens that
manipulate conserved cellular pathways, organelles, and cargo to convert the phagosome …