[HTML][HTML] Integrative toxicogenomics: Advancing precision medicine and toxicology through artificial intelligence and OMICs technology

AV Singh, V Chandrasekar, N Paudel, P Laux… - Biomedicine & …, 2023 - Elsevier
More information about a person's genetic makeup, drug response, multi-omics response,
and genomic response is now available leading to a gradual shift towards personalized …

Effect-directed analysis supporting monitoring of aquatic environments—an in-depth overview

W Brack, S Ait-Aissa, RM Burgess, W Busch… - Science of the Total …, 2016 - Elsevier
Aquatic environments are often contaminated with complex mixtures of chemicals that may
pose a risk to ecosystems and human health. This contamination cannot be addressed with …

Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009

… Chemical Agency (ECHA) and European Food … - EFSA …, 2018 - Wiley Online Library
This Guidance describes how to perform hazard identification for endocrine‐disrupting
properties by following the scientific criteria which are outlined in Commission Delegated …

Potential inhibitors for novel coronavirus protease identified by virtual screening of 606 million compounds

A Fischer, M Sellner, S Neranjan, M Smieško… - International journal of …, 2020 - mdpi.com
The rapid outbreak of the novel severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) in China followed by its spread around the world poses a serious global concern for …

Predicting drug metabolism: experiment and/or computation?

J Kirchmair, AH Göller, D Lang, J Kunze… - Nature reviews Drug …, 2015 - nature.com
Drug metabolism can produce metabolites with physicochemical and pharmacological
properties that differ substantially from those of the parent drug, and consequently has …

[HTML][HTML] Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in …

KJ Groh, RN Carvalho, JK Chipman, ND Denslow… - Chemosphere, 2015 - Elsevier
Adverse outcome pathways (AOPs) organize knowledge on the progression of toxicity
through levels of biological organization. By determining the linkages between toxicity …

Qsar in natural non-peptidic food-related compounds: current status and future perspective

Y Zhao, Y Xia, Y Yu, G Liang - Trends in Food Science & Technology, 2023 - Elsevier
Background Bioactive factors in functional foods play a crucial role in performing their
specific functions. These factors have their own specific physical and chemical properties …

Scientific Opinion on the hazard assessment of endocrine disruptors: scientific criteria for identification of endocrine disruptors and appropriateness of existing test …

EFSA Scientific Committee - EFSA Journal, 2013 - Wiley Online Library
Upon request of the European Commission, the Scientific Committee (SC) of the European
Food Safety Authority reviewed existing information related to the testing and assessment of …

Endocrine Disruptome An Open Source Prediction Tool for Assessing Endocrine Disruption Potential through Nuclear Receptor Binding

K Kolšek, J Mavri, M Sollner Dolenc, S Gobec, S Turk - 2014 - ACS Publications
Predicting the endocrine disruption potential of compounds is a daunting but essential task.
Here we report a new tool for this purpose that we have termed Endocrine Disruptome. It is a …

[HTML][HTML] High-efficiency effect-directed analysis (EDA) advancing toxicant identification in aquatic environments: Latest progress and application status

W Luo, L Chou, Q Cui, S Wei, X Zhang, J Guo - Environment International, 2024 - Elsevier
Facing the great threats to ecosystems and human health posed by the continuous release
of chemicals into aquatic environments, effect-directed analysis (EDA) has emerged as a …