Human bone marrow stromal cells (hBMSCs, also known as bone marrow-derived
mesenchymal stem cells) are a population of progenitor cells that contain a subset of …

The role of cytosolic calcium oscillation has long been recognized in the regulation of
cellular and molecular interactions. Information embedded in calcium oscillation can provide …

Realization of the exciting potential for stem‐cell‐based biomedical and therapeutic
applications, including tissue engineering, requires an understanding of the cell‐cell and …

Platelet release by megakaryocytes is regulated by a concert of environmental and
autocrine factors. We previously showed that constitutively released adenosine diphosphate …

Estrogens are essential for female reproduction and overall well-being, and estrogens in the
circulation are largely synthesized in ovarian granulosa cells. Using primary cultures of …

Heterotrimeric G proteins transduce the signals of the largest family of membrane receptors
(G protein coupled receptors, GPCR) hence triggering the activation of a wide variety of …

Abscisic acid (ABA) is a phytohormone involved in pivotal physiological functions in higher
plants. Recently, ABA has been proven to be also secreted and active in mammals, where it …

MicroRNAs (miRNAs) are abundant small regulatory RNAs with multiple roles in cell fate
determination. The processes regulating cellular miRNA levels are still unclear and …

Background: β2‐Glycoprotein I is the most relevant antigen in antiphospholipid syndrome.
We have shown that binding of dimerized β2‐GPI to platelets via ApoER2′ sensitizes …

In hematopoietic stem cells and megakaryocytes, the thrombopoietin (TPO) receptor signals
to control proliferation, maturation, and antiapoptosis. In the anucleated platelet, much of this …