Three processes act in series to accurately replicate the eukaryotic nuclear genome. The
major replicative DNA polymerases strongly prevent mismatch formation, occasional …

DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important
cellular functions. In its role in post-replication repair, MMR safeguards the genome …

DNA mismatch repair corrects replication errors, thus reducing mutation rates and
microsatellite instability. Genetic defects in this pathway cause Lynch syndrome and various …

The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and
Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the …

The field of DNA mismatch repair (MMR) has rapidly expanded after the discovery of the
MutHLS repair system in bacteria. By the mid 1990s yeast and human homologues to …

The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The
process is initiated by recognition of a DNA mismatch, and validated by ATP and the …

To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch
repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an …

Premature ovarian insufficiency (POI) is a frequent pathology that affects women under 40
years of age, characterized by an early cessation of menses and high FSH levels. Despite …

The majority of Lynch syndrome (LS), also known as hereditary non-polyposis colorectal
cancer (HNPCC), has been linked to heterozygous defects in DNA mismatch repair (MMR) …

MutS protein recognizes mispaired bases in DNA and targets them for mismatch repair. Little
is known about the transient conformations of MutS as it signals initiation of repair. We have …