Plasmodium parasites responsible for the disease malaria reside within erythrocytes. Inside
this niche host cell, parasites internalize and digest host hemoglobin to source amino acids …

For more than one hundred years, several treatments against malaria have been proposed
but they have systematically failed, mainly due to the occurrence of drug resistance in part …

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …

The malaria parasite Plasmodium falciparum has a great capacity for evolutionary
adaptation to evade host immunity and develop drug resistance. Current understanding of …

Successful establishment of CRISPR/Cas9 genome editing technology in Plasmodium spp.
has provided a powerful tool to transform Plasmodium falciparum into a genetically more …

Malaria parasites evade immune detection by growth and replication within erythrocytes.
After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of …

The ability of the malaria parasite Plasmodium vivax to invade erythrocytes is dependent on
the expression of the Duffy blood group antigen on erythrocytes. Consequently, Africans …

Epigenetic regulatory mechanisms are central to the development and survival of all
eukaryotic organisms. These mechanisms critically depend on the marking of chromatin …

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the
major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we …

Human malaria is a devastating disease and a major cause of poverty in resource-limited
countries. To develop and adapt within hosts Plasmodium falciparum undergoes drastic …