Mitochondria are cellular organelles critical for ATP production and are particularly relevant
to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion …

Aging is a key independent risk factor of various vascular diseases, for which the regulatory
mechanisms remain largely unknown. Bromodomain-containing protein 4 (BRD4) is a …

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …

Objective: To determine macrophage-specific alterations in epigenetic enzyme function
contributing to the development of abdominal aortic aneurysms (AAAs). Background: AAA is …

Abstract Background Thoracic Aortic Aneurysms (TAAs) develop asymptomatically and are
characterized by dilatation of the aorta. This is considered a life-threatening vascular …

The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well
understood and only partially characterized. AAA are also complicated in case of bicuspid …

The quotation “a man is as old as his arteries,” attrib-uted to the English physician Thomas
Sydenham (1624–1689), demonstrates the early recognition of the role of the vasculature in …

Thoracic aortic aneurysm (TAA) is mainly sporadic and with higher incidence in the
presence of a bicuspid aortic valve (BAV) for unknown reasons. The lack of drug therapy to …

Objective Thoracic aortic aneurysm and dissection (TAAD) is a cardiovascular disease with
a high mortality rate. Aging is an important risk factor for TAAD. This study explored the …

Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its
asymptomatic nature posing diagnostic and monitoring challenges, thereby increasing the …