Cardiovascular aging: spotlight on mitochondria
MA Ali, R Gioscia-Ryan, D Yang… - American Journal of …, 2024 - journals.physiology.org
Mitochondria are cellular organelles critical for ATP production and are particularly relevant
to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion …
to cardiovascular diseases including heart failure, atherosclerosis, ischemia-reperfusion …
Epigenetic Reader Bromodomain-Containing Protein 4 in Aging-Related Vascular Pathologies and Diseases: Molecular Basis, Functional Relevance, and Clinical …
X Zheng, K Diktonaite, H Qiu - Biomolecules, 2023 - mdpi.com
Aging is a key independent risk factor of various vascular diseases, for which the regulatory
mechanisms remain largely unknown. Bromodomain-containing protein 4 (BRD4) is a …
mechanisms remain largely unknown. Bromodomain-containing protein 4 (BRD4) is a …
Identification and functional analysis of senescent cells in the cardiovascular system using omics approaches
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …
The histone methyltransferase SETDB2 modulates tissue inhibitors of metalloproteinase–matrix metalloproteinase activity during abdominal aortic aneurysm …
FM Davis, WJ Melvin, K Mangum, LC Tsoi… - Annals of …, 2023 - journals.lww.com
Objective: To determine macrophage-specific alterations in epigenetic enzyme function
contributing to the development of abdominal aortic aneurysms (AAAs). Background: AAA is …
contributing to the development of abdominal aortic aneurysms (AAAs). Background: AAA is …
Tissue and plasma proteomic profiling indicates AHSG as a potential biomarker for ascending thoracic aortic aneurysms
R Kazamia, A Keravnou, A Moushi, K Sokratous… - BMC cardiovascular …, 2023 - Springer
Abstract Background Thoracic Aortic Aneurysms (TAAs) develop asymptomatically and are
characterized by dilatation of the aorta. This is considered a life-threatening vascular …
characterized by dilatation of the aorta. This is considered a life-threatening vascular …
The endothelial transcription factor ERG mediates a differential role in the aneurysmatic ascending aorta with bicuspid or tricuspid aorta valve: a preliminary study
C Pisano, S Terriaca, MG Scioli, P Nardi… - International journal of …, 2022 - mdpi.com
The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well
understood and only partially characterized. AAA are also complicated in case of bicuspid …
understood and only partially characterized. AAA are also complicated in case of bicuspid …
Vascular Aging and Vascular Disease Have Much in Common!
The quotation “a man is as old as his arteries,” attrib-uted to the English physician Thomas
Sydenham (1624–1689), demonstrates the early recognition of the role of the vasculature in …
Sydenham (1624–1689), demonstrates the early recognition of the role of the vasculature in …
Analysis of Vascular Smooth Muscle Cells from Thoracic Aortic Aneurysms Reveals DNA Damage and Cell Cycle Arrest as Hallmarks in Bicuspid Aortic Valve Patients
A Martin-Blazquez, M Martin-Lorenzo… - Journal of Proteome …, 2024 - ACS Publications
Thoracic aortic aneurysm (TAA) is mainly sporadic and with higher incidence in the
presence of a bicuspid aortic valve (BAV) for unknown reasons. The lack of drug therapy to …
presence of a bicuspid aortic valve (BAV) for unknown reasons. The lack of drug therapy to …
Bioinformatics analysis of aging-related genes in thoracic aortic aneurysm and dissection
H Wan, D Liu, B Liu, M Sha, W Xia… - Frontiers in Cardiovascular …, 2023 - frontiersin.org
Objective Thoracic aortic aneurysm and dissection (TAAD) is a cardiovascular disease with
a high mortality rate. Aging is an important risk factor for TAAD. This study explored the …
a high mortality rate. Aging is an important risk factor for TAAD. This study explored the …
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
BH Ganizada, R JA Veltrop, AC Akbulut… - Basic Research in …, 2024 - Springer
Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its
asymptomatic nature posing diagnostic and monitoring challenges, thereby increasing the …
asymptomatic nature posing diagnostic and monitoring challenges, thereby increasing the …