Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover
in the body, and regulates inflammation, cell proliferation, and tissue regeneration,–. How …

During wound injury, efferocytosis fills the macrophage with a metabolite load nearly equal
to the phagocyte itself. A timely question pertains to how metabolic phagocytic signaling …

Regulatory T (Treg) cell responses and apoptotic cell clearance (efferocytosis) represent
critical arms of the inflammation resolution response. We sought to determine whether these …

The immunogenicity of cancer cells is an emerging determinant of anti‐cancer
immunotherapy. Beyond developing immunostimulatory regimens like dendritic cell‐based …

The term 'immunogenic cell death'(ICD) denotes an immunologically unique type of
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …

Although macrophages are widely recognized to have a profibrotic role in inflammation, we
have used a highly tractable CCl4-induced model of reversible hepatic fibrosis to identify …

Abstract Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central
role in infection by limiting the immune response to pathogens and thereby preventing …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …