The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused
by SARS-CoV-2 virus, has posed a serious threat to global public health and caused …

Albumin, the most abundant circulating protein in blood, is an essential protein which binds
and transports various drugs and substances, maintains the oncotic pressure of blood and …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Background Vascular complications are the leading cause of morbidity and mortality among
patients with type 1 and type 2 diabetes mellitus. These vascular abnormalities result of a …

Cardiovascular disease (CVD) is a major cause of death in patients with chronic kidney
disease (CKD). Both conditions are rising in incidence as well as prevalence, creating poor …

Microvascular and metabolic physiology are tightly linked. This Perspective reviews
evidence that 1) the relationship between hyperglycemia and microvascular dysfunction …

Chronic kidney disease1 (CKD) is a worldwide public health problem. In the United States,
there is a rising incidence and prevalence of kidney failure, with poor outcomes and high …

ContextMicroalbuminuria is a risk factor for cardiovascular (CV) events. The relationship
between the degree of albuminuria and CV risk is unclear. ObjectivesTo estimate the risk of …

Endothelial dysfunction is characterized by a shift of the actions of the endothelium toward
reduced vasodilation, a proinflammatory state, and prothrombic properties. It is associated …

Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin
superfamily of cell surface molecules and engages diverse ligands relevant to distinct …