Melatonin in cancer treatment: current knowledge and future opportunities

WH Talib, AR Alsayed, A Abuawad, S Daoud… - Molecules, 2021 - mdpi.com
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

The role of resveratrol in liver disease: A comprehensive review from in vitro to clinical trials

C Izzo, M Annunziata, G Melara, R Sciorio, M Dallio… - Nutrients, 2021 - mdpi.com
Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders.
Its administration can significantly increase the survival rate after liver transplantation …

Plants as a source of anticancer agents: From bench to bedside

WH Talib, S Daoud, AI Mahmod, RA Hamed, D Awajan… - Molecules, 2022 - mdpi.com
Cancer is the second leading cause of death after cardiovascular diseases. Conventional
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …

Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation

WH Talib, I Alsalahat, S Daoud, RF Abutayeh… - Molecules, 2020 - mdpi.com
Cancer is one of the main causes of death globally and considered as a major challenge for
the public health system. The high toxicity and the lack of selectivity of conventional …

Anti-cancer properties of resveratrol: a focus on its impact on mitochondrial functions

L Kursvietiene, DM Kopustinskiene, I Staneviciene… - Antioxidants, 2023 - mdpi.com
Cancer is one of the most serious public health issues worldwide, demanding ongoing
efforts to find novel therapeutic agents and approaches. Amid growing interest in the …

Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases

X Xiao, Q Hu, X Deng, K Shi, W Zhang, Y Jiang… - Pharmacological …, 2022 - Elsevier
As a source of various compounds, natural products have long been important and valuable
for drug development. Kaempferol (KP) is the most common flavonol with bioactive activity …

Hepatoprotective and therapeutic effects of resveratrol: A focus on anti‐inflammatory and antioxidative activities

S Chupradit, D Bokov, MY Zamanian… - Fundamental & …, 2022 - Wiley Online Library
Being the most essential organ in the body, the liver performs critical functions. Hepatic
disorders, such as alcoholic liver disease, hepatic steatosis, liver fibrosis, nonalcoholic fatty …

Non-coding RNAs and macrophage interaction in tumor progression

M Entezari, M Sadrkhanloo, M Rashidi, SE Asnaf… - Critical reviews in …, 2022 - Elsevier
The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor
malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage …

Tumor microenvironment remodeling in oral cancer: Application of plant derived-natural products and nanomaterials

HS Budi, B Farhood - Environmental research, 2023 - Elsevier
Oral cancers consist of squamous cell carcinoma (SCC) and other malignancies in the
mouth with varying degrees of invasion and differentiation. For many years, different …