[HTML][HTML] Targeting viral entry as a strategy for broad-spectrum antivirals
M Mazzon, M Marsh - F1000Research, 2019 - ncbi.nlm.nih.gov
The process of entry into a host cell is a key step in the life cycle of most viruses. In recent
years, there has been a significant increase in our understanding of the routes and …
years, there has been a significant increase in our understanding of the routes and …
Overcoming symmetry mismatch in vaccine nanoassembly through spontaneous amidation
Matching of symmetry at interfaces is a fundamental obstacle in molecular assembly. Virus‐
like particles (VLPs) are important vaccine platforms against pathogenic threats, including …
like particles (VLPs) are important vaccine platforms against pathogenic threats, including …
Targeting Ebola virus replication through pharmaceutical intervention
Introduction. The consistent emergence/reemergence of filoviruses into a world that
previously lacked an approved pharmaceutical intervention parallels an experience …
previously lacked an approved pharmaceutical intervention parallels an experience …
Single-cycle influenza virus vaccine generates lung CD8+ Trm that cross-react against viral variants and subvert virus escape mutants
MZM Zheng, TK Tan, F Villalon-Letelier, H Lau… - Science …, 2023 - science.org
Influenza virus–specific tissue-resident memory (Trm) CD8+ T cells located along the
respiratory tract provide cross-strain protection against a breadth of influenza viruses. We …
respiratory tract provide cross-strain protection against a breadth of influenza viruses. We …
Therapeutic monoclonal antibodies for Ebola virus infection derived from vaccinated humans
P Rijal, SC Elias, SR Machado, J Xiao, L Schimanski… - Cell reports, 2019 - cell.com
We describe therapeutic monoclonal antibodies isolated from human volunteers vaccinated
with recombinant adenovirus expressing Ebola virus glycoprotein (EBOV GP) and boosted …
with recombinant adenovirus expressing Ebola virus glycoprotein (EBOV GP) and boosted …
Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity
L Chauveau, A Bridgeman, TK Tan, R Beveridge… - EMBO …, 2021 - embopress.org
Abstract Cyclic GMP‐AMP (cGAMP) is an immunostimulatory molecule produced by cGAS
that activates STING. cGAMP is an adjuvant when administered alongside antigens. cGAMP …
that activates STING. cGAMP is an adjuvant when administered alongside antigens. cGAMP …
The shape of pleomorphic virions determines resistance to cell-entry pressure
Many enveloped animal viruses produce a variety of particle shapes, ranging from small
spherical to long filamentous types. Characterization of how the shape of the virion affects …
spherical to long filamentous types. Characterization of how the shape of the virion affects …
Structure–function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans
KYA Huang, P Rijal, H Jiang, B Wang… - Nature …, 2019 - nature.com
Little is known about the specificities and neutralization breadth of the H7-reactive antibody
repertoire induced by natural H7N9 infection in humans. We have isolated and …
repertoire induced by natural H7N9 infection in humans. We have isolated and …
Structures of Ebola virus glycoprotein complexes with tricyclic antidepressant and antipsychotic drugs
A large number of Food and Drug Administration (FDA)-approved drugs have been found to
inhibit the cell entry of Ebola virus (EBOV). However, since these drugs have various primary …
inhibit the cell entry of Ebola virus (EBOV). However, since these drugs have various primary …
Structure-based in silico screening identifies a potent ebolavirus inhibitor from a traditional Chinese medicine library
Potent Ebolavirus (EBOV) inhibitors will help to curtail outbreaks such as that which
occurred in 2014–16 in West Africa. EBOV has on its surface a single glycoprotein (GP) …
occurred in 2014–16 in West Africa. EBOV has on its surface a single glycoprotein (GP) …