Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …

Tissue-resident immune cells are important for organ homeostasis and defense. The
epithelium may contribute to these functions directly or by cross-talk with immune cells. We …

Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases,
with its role in transcription of hundreds of gene well established in the literature. This has …

Mast cells are tissue-resident, innate immune cells that play a key role in the inflammatory
response and tissue homeostasis. Mast cells accumulate in the tumor stroma of different …

Mast cells are central players in allergy and asthma, and their dysregulated responses lead
to reduced quality of life and life-threatening conditions such as anaphylaxis. The RNA …

Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous
wheal development and/or angioedema for more than six weeks and at least twice a week …

The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic
secretagogues and neurokinins. A number of commonly used small-molecule drugs (eg …

Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …