Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Heart morphogenesis is a complex and dynamic process that has captivated researchers for
almost a century. This process involves three main stages, during which the heart …

Aims Investigating human heart development and applying this to deviations resulting in
disease is incomplete without molecular characterization of the cell types required for …

The field of developmental metabolism is experiencing a technological revolution that is
opening entirely new fields of inquiry. Advances in metabolomics, small-molecule sensors …

The initiation of heartbeat is an essential step in cardiogenesis in the heart primordium, but it
remains unclear how intracellular metabolism responds to increased energy demands after …

How two-chambered hearts in basal vertebrates have evolved from single-chamber hearts
found in ancestral chordates remains unclear. Here, we show that the teleost sinus venosus …

Understanding organ morphogenesis requires a precise geometrical description of the
tissues involved in the process. The high morphological variability in mammalian embryos …

The article will briefly introduce the high-resolution episcopic microscopy (HREM) technique
and will focus on its potential for researching cardiovascular development and remodelling …

Congenital heart disease (CHD) affects about 1 in 100 newborns and its causes are
multifactorial. In the embryo, blood flow within the heart and vasculature is essential for …

Transposition of great arteries (TGA) is a complex congenital heart disease whose etiology
is still unknown. This defect has been associated, at least in part, with genetic abnormalities …