Nano-pregabalin effectively mitigates Glut, CGRP and NE neurotransmitters abnormalities in the brain of gamma irradiated rats with reserpine-induced fibromyalgia …

EM Samy, RR Radwan, FM Mosallam, HA Mohamed - Neuropharmacology, 2024 - Elsevier
Aims Fibromyalgia (FM) is an idiopathic syndrome with painful burdensome symptoms.
Radiotherapy is one of the main therapeutic modalities for treating various malignancies and …

[PDF][PDF] Histological liver, kidney, and brain changes induced by pregabalin drug in albino rats

BA Salah, MY Al-Fathi, MK Shindala - Iraqi J Vet Sci, 2024 - iasj.net
Pregabalin is a commonly used medication for the treatment of pain associated with
neuropathic conditions, but there has been little research on its harmful consequences. This …

Unraveling the Hippocampal Molecular and Cellular Alterations behind Tramadol and Tapentadol Neurobehavioral Toxicity

C Soares-Cardoso, S Leal, SI Sá, R Dantas-Barros… - Pharmaceuticals, 2024 - mdpi.com
Tramadol and tapentadol are chemically related opioids prescribed for the analgesia of
moderate to severe pain. Although safer than classical opioids, they are associated with …

A novel tramadol–polycaprolactone implant could palliate heroin conditioned place preference and withdrawal in rats: behavioral and neurochemical study

SA Elshebiney, RA Elgohary… - Behavioural …, 2024 - journals.lww.com
Drug dependence is a chronic brain disease characterized by craving and recurrent
episodes of relapse. Tramadol HCl is a promising agent for withdrawal symptoms …

Examination of optical coherence tomography findings in patients with pregabalin use disorder

OHT Kılıç, ZN Bayram, P Kiyat, O Karti, A Aral… - PeerJ, 2024 - peerj.com
Background Pregabalin abuse is a rapidly growing health problem worldwide, and little is
known about the effects of prolonged high-dose use in patients with pregabalin use …

The Prophylactic Role of Chrysin against Clonazepam Induced Brain Toxicity in Male Albino Rats

RM Mosaad, MA Ibrahim… - UTTAR PRADESH …, 2024 - article.researchpromo.com
Background: The bioactive substance chyrus is found in bee propolis and all plants of the
species Passiflora. It is well recognized to have neuroprotective properties and a wide range …

[PDF][PDF] Comparative Study of the Hepatotoxic and Nephrotoxic Effects of Gabapentin versus Clonazepam in Rats

MA Khattab, FAWA Maksoud, ME Eldein, W Awad… - 2024 - multiarticlesjournal.com
Background: Gabapentin is an anticonvulsant adjunct and a neuropathic pain analgesic that
has become widely abused in Egypt in the last decade after scheduling its analogue …

CLONAZEPAM INDUCED SUB CHRONIC HEPATORENAL TOXICITY IN RATS AND THE PROTECTIVE ROLE OF ALPHA-TOCOPHEROL

MA Khattab, FAW Abdel Maksoud… - The Egyptian Journal …, 2023 - journals.ekb.eg
Background: Clonazepam (CZP) is an antiepileptic drug approved in 1976 by Food and
Drug Administration (FDA) for treatment of various types of seizures, Clonazepam has a high …

Nephrotoxicity after sub chronic misuse of gabapentin and the protective role of alpha-tocopherol, an experimental study

M El-Kattan, MA Khattab… - Zagazig Journal of …, 2024 - zjfm.journals.ekb.eg
Background: In Egypt, gabapentin (GBP) misuse and abuse have been increased in the last
decade after scheduling of its analogue pregabalin in 2012. Although many studies …

Self-Medication and Risk of Pregabalin Abuse

AS Ibrahim, AA Abdelaziz - NeuroQuantology, 2022 - search.proquest.com
Pregabalin is one of a group of gabapentinoids approved by the Food and Drug
Administration (FDA) in 2004 for treatment of neuropathic pain. It is a structural analogue of …