Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

Primary cilia are specialized microtubule‐based signaling organelles that convey
extracellular signals into a cellular response in most vertebrate cell types. The physiological …

Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …

Background: The primary cilium is a singular cellular structure that extends from the surface
of many cell types and plays crucial roles in vertebrate development, including that of the …

Mechanotransduction refers to the conversion of mechanical forces into biochemical or
electrical signals that initiate structural and functional remodeling in cells and tissues. The …

Since the beginning of the millennium, research in primary cilia has revolutionized our way
of understanding how cells integrate and organize diverse signaling pathways during …

Primary cilia are dynamic signaling organelles that project from the cell surface to sense
diverse chemical, physical and morphogenetic cues. Ciliary defects therefore cause …

Endocardial cells are cardiac endothelial cells that line the interior of the heart tube.
Historically, their contribution to cardiac development has mainly been considered from a …