miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

The adult ventricular–subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis

DA Lim, A Alvarez-Buylla - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Treating cancer with microRNA replacement therapy: A literature review

N Hosseinahli, M Aghapour, PHG Duijf… - Journal of cellular …, 2018 - Wiley Online Library
microRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression post‐
transcriptionally by interfering with the translation of one or more target mRNAs. The unique …

Characterization of human plasma-derived exosomal RNAs by deep sequencing

X Huang, T Yuan, M Tschannen, Z Sun, H Jacob, M Du… - BMC genomics, 2013 - Springer
Background Exosomes, endosome-derived membrane microvesicles, contain specific RNA
transcripts that are thought to be involved in cell-cell communication. These RNA transcripts …

Genome-wide association study identifies five new schizophrenia loci

Nature genetics, 2011 - nature.com
We examined the role of common genetic variation in schizophrenia in a genome-wide
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

[HTML][HTML] Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

X Xia, Y Wang, Y Huang, H Zhang, H Lu… - Progress in …, 2019 - Elsevier
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU. 1 pathway

ED Ponomarev, T Veremeyko, N Barteneva… - Nature medicine, 2011 - nature.com
MicroRNAs are a family of regulatory molecules involved in many physiological processes,
including differentiation and activation of cells of the immune system. We found that brain …

Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity

A Jaggupilli, E Elkord - Journal of Immunology Research, 2012 - Wiley Online Library
Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis,
heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a …

Mesenchymal stem cells as natural biofactories for exosomes carrying miR-124a in the treatment of gliomas

FM Lang, A Hossain, J Gumin, EN Momin… - Neuro …, 2018 - academic.oup.com
Background MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However,
which miRs are most effective against glioblastomas and how these miRs should be …