This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Different calcium signals in the endothelium and smooth muscle target different types of
Ca2+-sensitive K+ channels to modulate vascular function. These differential calcium …

BK large conductance voltage-and calcium-activated potassium channels respond to
elevations in intracellular calcium and membrane potential depolarization, braking …

The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and
questions concerning its roles, especially as these change with development, disease, and …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Smooth muscle (SM) is essential to all aspects of human physiology and, therefore, key to
the maintenance of life. Ion channels expressed within SM cells regulate the membrane …

Intracellular calcium ions are involved in the regulation of nearly every aspect of cell
function. In smooth muscle, Ca2+ can be delivered to Ca2+-sensitive effector molecules …

Smooth muscle cells are ultimately responsible for determining vascular luminal diameter
and blood flow. Dynamic changes in intracellular calcium are a critical mechanism …

Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …