Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected
individuals to control infection and live long, productive lives. However, HIV-1 infection …

Together, these findings provide evidence that the CNS can potentially act as a viral
reservoir of HIV-1. However, the majority of these studies were performed in historical …

The establishment of a long-lived viral reservoir is the key obstacle for achieving an HIV-1
cure. However, the anatomic, virologic, and immunologic features of the viral reservoir in …

The ability of HIV-1 to establish latent infection is a key obstacle to its eradication despite the
existence of effective antiretroviral drugs. The brain has been postulated as a reservoir for …

Non-human primates (NHPs) are the most relevant model of Acquired Immunodeficiency
Syndrome (AIDS) and neuroAIDS, being of great importance in explaining the pathogenesis …

Simian immunodeficiency virus (SIV) infection of pigtailed macaques is a highly
representative and well-characterized animal model for HIV neuropathogenesis studies that …

Combination antiretroviral therapy (cART) has led to a reduction in morbidity and mortality in
HIV-infected patients but therapy is lifelong and there is no cure for HIV. The major barriers …

Current HIV therapy is not curative regardless of how soon after infection it is initiated or how
long it is administered, and therapy interruption almost invariably results in robust viral …

Objective: HIV-associated neurocognitive deficits remain a challenge despite suppressive
combined antiretroviral therapy. Given the association between HIV-induced central nervous …

It is difficult to study the pathogenesis of human immunodeficiency virus (HIV)-associated
neurocognitive disorder (HAND) in living patients because central nervous system (CNS) …