We explore the potential of clamp-G nucleobase-modified peptide nucleic acids (cGPNAs)
as microRNA and messenger RNA inhibitors. For proof of concept, we target miR-155, which …

Transcription factors (TFs) are proteins essential for the regulation of gene expression, and
they regulate the genes involved in different cellular processes, such as proliferation …

Introduction Antisense oligonucleotide (ASO) was established as a viable therapeutic option
for genetic disorders. ASOs can target RNAs implicated in various diseases, including …

MicroRNA-141-3p plays a detrimental role in the pathology of ischemic stroke, presenting a
new target for stroke treatment. This study introduces and validates a novel class of peptide …

Background Emerging perspectives on tumor metabolism reveal its heterogeneity, a
characteristic yet to be fully explored in gliomas. To advance therapies targeting metabolic …

Umek et al. reported a promising AGO with a clamp design to target the doublestranded
DNA (dsDNA). Umek et al. designed a series of mixmers made of locked nucleic acid (LNA) …

Advancements in cell-penetrating monoclonal antibody treatment - PMC Skip to main content
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