Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …