Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop
fashion is necessary to establish causative links between biochemical processes within the …

Because of great diversity of chemical and physical properties and wide ranges of
concentrations of different metabolites in metabolome samples, metabolome analysis is a …

Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

Cardiomyopathy and heart failure are common manifestations in mitochondrial disease
caused by deficiencies in the oxidative phosphorylation (OXPHOS) system of mitochondria …

Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …

Rationale: Maintaining iron homeostasis is essential for proper cardiac function. Both iron
deficiency and iron overload are associated with cardiomyopathy and heart failure via …

The dopamine projection from ventral tegmental area (VTA) to nucleus accumbens (NAc) is
critical for motivation to work for rewards and reward-driven learning. How dopamine …

Altered expression of mitochondrial DNA (mtDNA) occurs in ageing and a range of human
pathologies (for example, inborn errors of metabolism, neurodegeneration and cancer) …

Untargeted methods are typically used in the detection and discovery of small organic
compounds in metabolomics research, and ultra-high-performance liquid chromatography …

Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals
triggering the release of mtDNA from mitochondria remain enigmatic. Here, we show that …