Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Sonodynamic therapy (SDT) is a noninvasive technique for local antitumor treatment;
however, its clinical application is often limited by the low tumor accumulation of SDT …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

With aging, the nervous system gradually undergoes degeneration. Increased oxidative
stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are …

Dysregulation of macroautophagy/autophagy contributes to the delay of wound healing in
diabetic skin. N6-methyladenosine (m6A) RNA modification is known to play a critical role in …

Autophagy, self-eating, is a pivotal catabolic mechanism that ensures homeostasis and
survival of the cell in the face of stressors as different as starvation, infection, or protein …

In recent years, progress in nanotechnology provided new tools to treat cancer more
effectively. Advances in biomaterials tailored for drug delivery have the potential to …

Background There are currently no disease-modifying therapeutics for Parkinson's disease
(PD). Although extensive efforts were undertaken to develop therapeutic approaches to …

Intracellular pathogens have evolved various efficient molecular armaments to subvert
innate defenses. Cellular ubiquitination, a normal physiological process to maintain …